Hepatotoxicity of the ethanolic extracts of enantia chlorantha root on wistar albino rats
Table Of Contents
- TITLE PAGE ICERTIFICATION IIDEDICATION IIIACKNOWLEDGEMENT IVTABLE OF CONTENT VABSTRACT IXCHAPTER ONE1.0 INTRODUCTION
- 11.1BACKGROUND OF THE STUDY
- 11.2AIMS AND OBJECTIVES
- 61.3STATEMENT OF PROBLEM
- 71.4LIMITATION OF STUDY
- 71.5SIGNIFICANCE OF THE STUDY 8CHAPTER TWO2.0 LITERATURE REVIEW
- 92.1GENERAL DESCRIPTION OF Enantia chlorontha
- 102.2ECOLOGICAL DISTRIBUTION OFEnantia chlorantha
- 102.3MANAGEMENT AND PROPAGATION PRACTICES
- 112.4FUNCTIONAL USES
- 122.5TOXICITY
- 132.6HEPATOTOXICITY
- 172.7LIVER 202.
- 7.1LIVER ENZYME 222.
- 7.2SOME PATTERN OF LIVER INJURY 232.
- 7.3TREATMENT/PROGNOSIS OF LIVER DAMAGE
- 282.8THE ALBINO RATS
- 292.9PHYTOCHEMICAL COMPOUNDS 31CHAPTER THREE3.0 MATERIALS AND METHODS
- 323.1COLLECTION, IDENTIFICATION ANDPROCESSING OF PLANT MATERIAL 323.
- 1.1EXTRACTION OF PLANT MATERIAL 333.
- 1.2DETERMINATION OF THE WEIGHT OFDRIED EXTRACT
- 343.2PHYTOCHEMCIAL ANALYSIS
- 353.3EXPERIMENTAL ANIMAL
- 433.4DETERMINATION OF DOSAGE OF THE PLANTEXTRACT FOR ANIMAL FEEDING
- 433.5GROUPING OF ANIMAL AND ADMINISTRATIONOF PLANT EXTRACT
- 443.6FEEDING METHOD
- 453.7PROCEDURES FOR BLOOD SAMPLE COLLECTION 463.
- 7.1ALANINE AMINOTRANSFERASE TEST (ALT)METHOD FOR ALT TEST 473.
- 7.2ASPARTATE ANIMOTRANSFERASE: (AST)METHOD FOR AST TEST 483.
- 7.3ALKALINE PHOUSPHATASE: (ALP)METHOD FOR ALP TEST 49CHAPTER FOUR4.0 RESULTS
- 504.1RESULT OF THE PHOTOCHEMICALANALYSIS OF THE ETHANOLIC EXTRACTOF Enantia chlorontha
- 504.2HEPATOTOXICITY ASSAY 55CHAPTER FIVE5.1 DISCUSSION
- 585.2CONCLUSION
- 605.3RECOMMENDATION 60REFERENCES 61.
Thesis Abstract
The root of Enantia chlorontha was assayed for its hepatotoxicity effect. Extacts from the root were made using 95% ethanol. The root extracts were administered orally to 15 wistar albino rats and varying doses. 5 rats were kept as control group. The effect of the extracts was determined by assaying for the levels of serum-liver enzymes acting as biochemical makers. Liver enzymes assayed included Aspartate aminotransferase (AST), Alanin aminiotransferase (ALT) and alkaline phophatase (ALP). Comparison of the enzyme levels of the control group with these of the group administered with the rot extract revealed a significant elevation of liver enzyme levels (P
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