Feeding difficulties and orofacial myofunctional disorder in patients with hepatic glycogen storage diseases
Table Of Contents
Chapter ONE
INTRODUCTION
- 1.1Introduction
- 1.2Background of Study
- 1.3Problem Statement
- 1.4Objective of Study
- 1.5Limitation of Study
- 1.6Scope of Study
- 1.7Significance of Study
- 1.8Structure of the Research
- 1.9Definition of Terms
Chapter TWO
LITERATURE REVIEW
- 2.1Overview of Feeding Difficulties
- 2.2Understanding Orofacial Myofunctional Disorders
- 2.3Relationship Between Hepatic Glycogen Storage Diseases and Feeding Difficulties
- 2.4Impact of Orofacial Myofunctional Disorders on Patients
- 2.5Diagnosis and Assessment of Feeding Difficulties in Patients
- 2.6Treatment Approaches for Orofacial Myofunctional Disorders
- 2.7Case Studies on Patients with Hepatic Glycogen Storage Diseases
- 2.8Research on Feeding Difficulties and Orofacial Myofunctional Disorders
- 2.9Current Trends and Developments in the Field
- 2.10Gaps in Literature and Research Needs
Chapter THREE
RESEARCH METHODOLOGY
- 3.1Research Methodology Overview
- 3.2Research Design and Approach
- 3.3Sampling Techniques and Participants
- 3.4Data Collection Methods
- 3.5Data Analysis Procedures
- 3.6Ethical Considerations
- 3.7Validity and Reliability of Data
- 3.8Limitations of the Research Methodology
Chapter FOUR
DATA PRESENTATION AND ANALYSIS
- 4.1Overview of Findings
- 4.2Analysis of Feeding Difficulties in Patients with Hepatic Glycogen Storage Diseases
- 4.3Examination of Orofacial Myofunctional Disorders in the Study Population
- 4.4Comparison of Treatment Outcomes for Patients with and without Orofacial Myofunctional Disorders
- 4.5Factors Influencing Feeding Difficulties and Orofacial Myofunctional Disorders
- 4.6Discussion on the Relationship Between Hepatic Glycogen Storage Diseases and Orofacial Myofunctional Disorders
- 4.7Recommendations for Clinical Practice and Further Research
- 4.8Implications for Healthcare Providers
Chapter FIVE
SUMMARY, CONCLUSION AND RECOMMENDATIONS
- 5.1Summary of Findings
- 5.2Conclusion and Interpretation of Results
- 5.3Contributions to the Field of Medicine
- 5.4Practical Applications and Recommendations
- 5.5Future Research Directions
Thesis Abstract
Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism whose dietary treatment involves uncooked cornstarch administration and restriction of simple carbohydrate intake. The prevalence of feeding difficulties (FDs) and orofacial myofunctional disorders (OMDs) in these patients is unknown. Objective To ascertain the prevalence of FDs and OMDs in GSD. Methods This was a cross-sectional, prospective study of 36 patients (19 males; median age, 12.0 years; range, 8.0–18.7 years) with confirmed diagnoses of GSD (type Ia = 22; Ib = 8; III = 2; IXa = 3; IXc = 1). All patients were being treated by medical geneticists and dietitians. Evaluation included a questionnaire for evaluation of feeding behavior, the orofacial myofunctional evaluation (AMIOFE), olfactory and taste performance (Sniffin’ Sticks and Taste Strips tests), and facial anthropometry. Results Nine (25%) patients had decreased olfactory perception, and four (11%) had decreased taste perception for all flavours. Eight patients (22.2%) had decreased perception for sour taste. Twenty-six patients (72.2%) had FD, and 18 (50%) had OMD. OMD was significantly associated with FD, tube feeding, selective intake, preference for fluid and semisolid foods, and mealtime stress (p < 0.05). Thirteen patients (36.1%) exhibited mouth or oronasal breathing, which was significantly associated with selective intake (p = 0.011) and not eating together with the rest of the family (p = 0.041). Lower swallowing and chewing scores were associated with FD and with specific issues related to eating behavior (p < 0.05). Conclusion There is a high prevalence of FDs and OMDs in patients with GSD. Eating behavior, decreased taste and smell perception, and orofacial myofunctional issues are associated with GSD.
Thesis Overview
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