Exploring the role of microRNAs in the regulation of gene expression in cancer cells

Thesis Abstract

Abstract
This thesis investigates the crucial role of microRNAs (miRNAs) in the regulation of gene expression in cancer cells. The dysregulation of miRNAs has been implicated in various aspects of cancer development and progression, making them attractive targets for cancer therapy. Chapter one provides an introduction to the study, highlighting the background information on miRNAs, the problem statement regarding their dysregulation in cancer, the objectives of the study, limitations, scope, significance, and the structure of the thesis. Additionally, key terms related to miRNAs and cancer are defined to aid in understanding the subsequent chapters. Chapter two presents a comprehensive literature review encompassing ten key areas related to miRNAs and cancer. The review synthesizes existing knowledge on the role of miRNAs in cancer progression, highlighting their potential as diagnostic biomarkers and therapeutic targets. Chapter three details the research methodology employed in this study, including the selection of cancer cell lines, miRNA profiling techniques, data analysis methods, and validation approaches. The chapter also discusses the ethical considerations and challenges faced during the research process. In chapter four, the findings of the study are extensively discussed, focusing on the identified miRNAs involved in regulating gene expression in cancer cells. The results shed light on the intricate mechanisms through which miRNAs modulate key signaling pathways implicated in cancer development, providing novel insights into potential therapeutic strategies. Lastly, chapter five presents the conclusion and summary of the thesis, summarizing the key findings, implications, and future directions for research in this field. The study underscores the importance of miRNAs as critical players in cancer pathogenesis and highlights the potential for targeting miRNAs in cancer therapy. Overall, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer and provides a foundation for further research in this area.