Exploring the role of microRNAs in cancer progression and potential therapeutic targets

Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in post-transcriptional gene regulation and are known to be dysregulated in various diseases, including cancer. This thesis explores the role of miRNAs in cancer progression and identifies potential therapeutic targets for cancer treatment. The study focuses on understanding the molecular mechanisms by which miRNAs contribute to cancer development and progression, as well as their potential as biomarkers and therapeutic targets in cancer therapy. The first part of the thesis provides an introduction to miRNAs, outlining their biogenesis, function, and dysregulation in cancer. The background of the study discusses the significance of miRNAs in cancer biology and the potential implications for cancer treatment. The problem statement highlights the need to further investigate the specific roles of miRNAs in different types of cancer and the challenges in targeting miRNAs for therapeutic purposes. The objectives of the study are to identify key miRNAs involved in cancer progression, elucidate their mechanisms of action, and explore their potential as therapeutic targets. The limitations of the study are also discussed, including the complexity of miRNA regulation and the challenges in translating miRNA-based therapies to clinical practice. The scope of the study outlines the specific cancer types and miRNAs that will be investigated, while the significance of the study emphasizes the potential impact of miRNA research on cancer treatment. The structure of the thesis is detailed, outlining the chapters and sub-sections that will be covered. The definitions of key terms related to miRNAs and cancer biology are provided to ensure clarity and understanding throughout the thesis. The literature review section synthesizes existing knowledge on the role of miRNAs in cancer progression, highlighting key studies and findings. The research methodology describes the experimental approaches and techniques that will be used to investigate miRNA function in cancer cells, including cell culture, molecular biology assays, and bioinformatics analysis. The discussion of findings section presents the results of the study, including the identification of key miRNAs associated with cancer progression and their downstream targets. The implications of these findings for cancer therapy and potential strategies for targeting miRNAs are discussed in detail. In conclusion, this thesis provides a comprehensive analysis of the role of miRNAs in cancer progression and highlights the potential for miRNAs to serve as therapeutic targets in cancer treatment. The summary of the project thesis underscores the key findings and their significance in advancing our understanding of cancer biology and developing novel therapeutic approaches for cancer patients.