INTRODUCTION
LITERATURE REVIEW
RESEARCH METHODOLOGY
DATA PRESENTATION AND ANALYSIS
SUMMARY, CONCLUSION AND RECOMMENDATIONS
Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.
📚 Over 50,000 Research Thesis
📱 100% Offline: No internet needed
📝 Over 98 Departments
🔍 Thesis-to-Journal Publication
🎓 Undergraduate/Postgraduate Thesis
📥 Instant Whatsapp/Email Delivery
This research aims to develop a practical framework that combines sustainability metrics with existing cost estimation models used in construction projects. The...
This research focuses on finding ways to improve how well catalysts perform by changing their surface properties. Catalysts are substances that speed up chemica...
This research is about developing a practical model or framework to help companies incorporate sustainable practices into their strategic sourcing decisions. St...
This research focuses on understanding how public organizations can become more innovative by improving their internal capabilities, which is known as instituti...
This research aims to develop a clear framework that shows how emotional regulation and cognitive flexibility can work together to help adolescents manage their...
This research aims to understand how social media influences political polarization, which is the growing division between different political groups. As more p...
This research aims to create a comprehensive and practical model to help physiotherapists better manage patients with chronic low back pain. Chronic low back pa...
This research aims to develop a comprehensive framework that explains how the autonomic nervous system (ANS) controls and coordinates cardiovascular functions. ...
This research explores how to help autonomous artificial agents, like robots or self-driving cars, make ethical decisions when facing dilemmas. As these machine...