Estrogen receptor β and breast cancer | Blazingprojects Postgraduate Thesis
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Estrogen receptor β and breast cancer

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Estrogen Receptor β
  • 2.2Role of Estrogen Receptor β in Breast Cancer
  • 2.3Gene Expression Regulation by Estrogen Receptor β
  • 2.4Cellular Signaling Pathways Involving Estrogen Receptor β
  • 2.5Therapeutic Targeting of Estrogen Receptor β in Breast Cancer
  • 2.6Clinical Implications of Estrogen Receptor β in Breast Cancer
  • 2.7Studies on Estrogen Receptor β and Breast Cancer
  • 2.8Emerging Research and Future Directions
  • 2.9Comparative Studies with Other Receptors
  • 2.10Summary of Literature Review

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Design and Methodology
  • 3.2Selection of Sample Population
  • 3.3Data Collection Techniques
  • 3.4Data Analysis Methods
  • 3.5Experimental Procedures
  • 3.6Ethical Considerations
  • 3.7Validation of Research Instruments
  • 3.8Statistical Tools and Software Used

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Research Findings
  • 4.2Estrogen Receptor β Expression in Breast Cancer Patients
  • 4.3Correlation between Estrogen Receptor β Levels and Disease Progression
  • 4.4Response to Estrogen Receptor β Targeted Therapy
  • 4.5Impact of Estrogen Receptor β Mutations on Treatment Outcomes
  • 4.6Comparison with Estrogen Receptor α in Breast Cancer
  • 4.7Discussion on Conflicting Studies
  • 4.8Implications of Findings on Clinical Practice

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Conclusion and Summary
  • 5.2Key Findings Recapitulation
  • 5.3Research Objectives Achievement
  • 5.4Contributions to Existing Knowledge
  • 5.5Recommendations for Future Research

Thesis Abstract

Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.

Thesis Overview

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