CARDIOPROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTAR RAT | Blazingprojects Postgraduate Thesis
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CARDIOPROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTAR RAT

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Cardioprotective Activities
  • 2.2N-Hexane Extract
  • 2.3Desmodium Velutinum Stem
  • 2.4Biological Activities of Desmodium Velutinum
  • 2.5Mechanisms of Cardioprotection
  • 2.6Previous Research on Cardioprotection
  • 2.7Animal Models for Cardioprotection Studies
  • 2.8Molecular Targets for Cardioprotection
  • 2.9Phytochemical Composition of N-Hexane Extract
  • 2.10Pharmacological Actions of N-Hexane Extract

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Selection of Research Design
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Data Analysis Procedures
  • 3.6Ethical Considerations
  • 3.7Validity and Reliability of Data
  • 3.8Statistical Tools Used

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Cardioprotective Effects of N-Hexane Extract
  • 4.2Evaluation of Desmodium Velutinum Stem Extract
  • 4.3Comparison with Other Plant Extracts
  • 4.4Dosage and Administration of Extract
  • 4.5Side Effects and Safety Profile
  • 4.6Discussion on Mechanisms of Action
  • 4.7Clinical Implications of Findings
  • 4.8Future Research Directions

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusions Drawn
  • 5.3Recommendations for Future Studies
  • 5.4Practical Implications of Research
  • 5.5Contribution to Scientific Knowledge

Thesis Abstract


  This study evaluates the cardioprotactive effect of N-hexane extract of Desmodium Velutinum stem on albino wistar rat. Rats used in this study were grouped into four and each group was fed differently. Rats in group one, three, and four were fed with the aid of a syringe without needle with 6ml of the lipoprotein food mixture containing 3.6g of the cow’s brain twice a day for seven days. Rats on group two was fed with only grower’s mash and water for seven days; rats in group three was later administered orally 2ml of dissolved vasoprin drug once in a day for 3 days.

Rats in group four were also administered orally 0.5ml of the liquid drug extract of Desmodium Velutinum stem once a day for 3 days. During these three (3) days, the rats were given grower’s mash and water. After the feeding period, the rate fed with the cow’s brain showed a significant increases in the activities of marker enzymes such as creatine kinase (CK), creatine kinase MB (CKMB), Aspartate Transaminase (AST), Alanine Transaminase (ALT), and lactate dehydrogenase. This study shows that N-hexane extract of Desmodium Velutinum stem possess cardio protective effect on albino wistar rats than the known drug (vasoprin) if only one can increase the dosage of the extract for a period of time.


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