THE EFFECT OF PTEROCARPUS MILDBREADII SEED ON PLASMAHDL CHOLESTEROL OF ALBINO RAT | Blazingprojects Postgraduate Thesis
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THE EFFECT OF PTEROCARPUS MILDBREADII SEED ON PLASMAHDL CHOLESTEROL OF ALBINO RAT

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Plasma HDL Cholesterol
  • 2.2Pterocarpus Mildbreadii Seed: Composition and Properties
  • 2.3Importance of HDL Cholesterol in Health
  • 2.4Effects of Plant Seeds on Cholesterol Levels
  • 2.5Previous Studies on Pterocarpus Mildbreadii Seed
  • 2.6Mechanisms of Action on HDL Cholesterol
  • 2.7Animal Models in Cholesterol Research
  • 2.8Role of Diet in Modulating Cholesterol
  • 2.9Pharmacological Interventions for Cholesterol
  • 2.10Current Trends in Managing Cholesterol Levels

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Design
  • 3.2Selection of Research Participants
  • 3.3Data Collection Methods
  • 3.4Experimental Procedures
  • 3.5Data Analysis Techniques
  • 3.6Ethical Considerations
  • 3.7Validity and Reliability
  • 3.8Statistical Tools Used

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Research Findings
  • 4.2Effect of Pterocarpus Mildbreadii Seed on Plasma HDL Cholesterol
  • 4.3Comparison with Control Groups
  • 4.4Variability in Response to Treatment
  • 4.5Potential Side Effects
  • 4.6Factors Influencing Results
  • 4.7Discussion on Mechanisms of Action
  • 4.8Implications for Future Studies

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusion
  • 5.3Recommendations for Further Research
  • 5.4Practical Applications
  • 5.5Contribution to Knowledge

Thesis Abstract

This work was carried out to investigate the effects of pterocarpus mildbreadii seed on the HDL- level of albino rats.High density lipoprotein(HDL) is a fraction of cholesterol,which helps to transport cholesterol from peripheral of cell to the liver.High density lipoprotein is carried out to investigate cardio vascular diseases.Fresh oha seed (pterocarpus mildbreadii seed) was collected from Amokwe in udi local government Area Enugu state. They were dried at room temperature for about a month in an open laboratory space, groud into coarse form and weighed on an electrical weighing balance. 3% tween-80 was prepared by dissolving 3% tween -80 in 97ml of distilled water. The grounded pterocarpus mildbreadii was dissolve in the 3% tween-80.A total of sixteen wistar abino rats used for this analysis. The rats were divided into 4(four) groups. Group 1contain 4 rats and received 0.5 each of 3% tween-80. Group 2 contain 5 rats and were administered with 1400mg/kg b.w of pteridocarpus mildreadii solution Group 3 contain 3 rats and were administered with 2600mg/kg. b.w of pteridocarpus mildbreadii solution. Group 4 contain 4 rats and were administered with 500mg/kg. b.w. of Edmard MRT complex.

Thesis Overview

INTRODUCTION1.0 Pterocarpus mildbreadii are trees with edible parts successfully budded, pterocarpus species (P.Soyauxii and P. mildbeadii are reported to have different patterns of leaf flush, one spontanous and the other intermitted making the first suitable for commercial production and the second the home production (Okafor 1978). Pterocarpus mildbreadii being the major case study both the vegetable and the seeds.The vegetable is majorly used in our various home for cooking. Pterocarpus mildbreadii (Oha seed) are not consumed by the people from the eastern part of Nigeria. So it cannot be majorly stated the content of this oha seed.The demand for vegetable oils as a result of diminishing source of oils and fats creates the needs for new sources as well as exploiting sources that are currently unexploited in order to supplement the existing ones (Minzangi et al. 2011).As industrialists continues to rely mostly on the popular vegetable oil like coconut oil, soyabeans oil, ground nut oil, palm oil etc. for the preparation and production of their various products.9Plant lipids also posses nutritive value and have an impact on human nutrition and the world economy.more than three quarters of the edible and industrial oils marketed annually are derived from seed and fruit triglycerol (Schimid & Ohlrogge, 2002). Seeds have nutritive and calorific value which makes them necessary in diets. They are good sources of edible oils and fats. The amount of energy provide by 1g of fat and oil when fully digested is more than twice as many joules of protein and carbohydrate do. Fats makes meals more satisfying, enrich its flavor and delay the unset of hunger (Odoemelan, 2005). Unfortunately, insufficient availability of animal protein and the costliness of available plant protein sources have also increased the need for research on revealing lesser known under-utilized legumes and oil seeds of nutritive value (Schimid & Ohlrogge, 2002).

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