Thesis Abstract

Abstract
Osteoarthritis is a common degenerative joint disease in dogs, leading to pain, stiffness, and reduced mobility. Traditional treatments have limitations in providing long-term relief. Stem cell therapy has emerged as a promising alternative for managing osteoarthritis by promoting tissue regeneration and reducing inflammation. This thesis investigates the effectiveness of stem cell therapy in treating osteoarthritis in dogs. The study begins with a comprehensive literature review to explore the current understanding of osteoarthritis pathophysiology, traditional treatment options, and the potential benefits of stem cell therapy. By analyzing ten key studies, the review highlights the advancements and challenges in using stem cells for treating osteoarthritis in veterinary medicine. The research methodology section outlines a detailed plan for conducting a clinical trial to evaluate the efficacy of stem cell therapy in dogs with osteoarthritis. The methodology includes selecting appropriate animal models, sample size determination, stem cell source identification, treatment protocols, outcome measures, and statistical analysis methods. The findings chapter presents the results of the clinical trial, including the assessment of pain levels, joint function, inflammation markers, and histological changes before and after stem cell therapy. The discussion section critically interprets the findings, compares them with existing literature, addresses limitations, and proposes future research directions. In conclusion, this thesis provides valuable insights into the potential of stem cell therapy as a novel treatment option for osteoarthritis in dogs. The study contributes to the growing body of evidence supporting the use of stem cells in veterinary orthopedics and underscores the importance of further research to optimize treatment protocols and enhance clinical outcomes. By investigating the effectiveness of stem cell therapy in treating osteoarthritis in dogs, this research aims to improve the quality of life for canine patients suffering from this debilitating condition.

Thesis Overview

The research project titled "Investigating the Effectiveness of Stem Cell Therapy in Treating Osteoarthritis in Dogs" aims to explore the potential benefits of stem cell therapy as a novel approach to managing osteoarthritis in canines. Osteoarthritis is a common degenerative joint disease in dogs, characterized by progressive cartilage degradation, inflammation, and pain, leading to impaired mobility and reduced quality of life. Current treatment options for osteoarthritis in dogs are limited and often focus on managing symptoms rather than addressing the underlying cause of the disease. Stem cell therapy has emerged as a promising regenerative medicine approach that harnesses the regenerative and anti-inflammatory properties of stem cells to promote tissue repair and regeneration. In the context of osteoarthritis, stem cell therapy holds the potential to not only alleviate symptoms but also to repair damaged cartilage and slow down disease progression. By investigating the effectiveness of stem cell therapy in treating osteoarthritis in dogs, this research aims to provide valuable insights into the therapeutic potential of this innovative treatment modality. The research will involve conducting a comprehensive literature review to explore the current understanding of osteoarthritis pathogenesis, existing treatment modalities, and the scientific basis of stem cell therapy for joint diseases. This will lay the foundation for designing and implementing a series of experimental studies to evaluate the efficacy and safety of stem cell therapy in a canine model of osteoarthritis. Key parameters such as pain levels, joint function, cartilage regeneration, and inflammatory markers will be assessed to determine the therapeutic impact of stem cell therapy on osteoarthritic joints. Furthermore, the research will investigate the mechanisms underlying the therapeutic effects of stem cell therapy, including its immunomodulatory and regenerative properties. Understanding how stem cells interact with the joint microenvironment and modulate the inflammatory response will provide valuable insights into the biological processes involved in osteoarthritis pathogenesis and repair. Overall, this research project seeks to advance our understanding of the potential benefits of stem cell therapy in managing osteoarthritis in dogs and pave the way for the development of innovative and effective treatment strategies for this debilitating joint disease. By elucidating the mechanisms of action and therapeutic outcomes of stem cell therapy, this research has the potential to revolutionize the field of veterinary medicine and improve the quality of life for dogs suffering from osteoarthritis.