Thesis Abstract

Abstract
Osteoarthritis is a common degenerative joint disease affecting many dogs worldwide, leading to pain, reduced mobility, and decreased quality of life. Despite various treatment options available, the search for more effective and innovative therapies continues. Stem cell therapy has emerged as a promising approach in regenerative medicine, showing potential in treating osteoarthritis in humans and animals. This thesis aims to explore the use of stem cell therapy in treating osteoarthritis in dogs, investigating its efficacy, safety, and long-term outcomes. The research begins with a comprehensive review of the background of osteoarthritis in dogs, highlighting the pathophysiology of the disease and current treatment modalities. The problem statement underscores the limitations of existing therapies and the need for novel approaches to address the challenges associated with osteoarthritis management in dogs. The objectives of the study include evaluating the effectiveness of stem cell therapy in alleviating clinical signs, improving joint function, and promoting cartilage regeneration in dogs with osteoarthritis. The methodology section outlines the research design, including the selection criteria for canine subjects, stem cell isolation and characterization, treatment protocols, assessment methods, and data analysis techniques. The study incorporates both in vitro and in vivo experiments to elucidate the mechanisms of action of stem cells in promoting joint repair and regeneration. The discussion of findings delves into the therapeutic potential of stem cell therapy in mitigating osteoarthritis progression, reducing inflammation, and enhancing tissue repair in affected joints. The significance of this research lies in its potential to revolutionize the management of osteoarthritis in dogs by offering a regenerative and personalized treatment approach. The results of this study may provide valuable insights into the clinical application of stem cell therapy in veterinary medicine, paving the way for future advancements in canine orthopedics and regenerative therapies. The conclusion summarizes the key findings, implications, and future directions for research in utilizing stem cell therapy for treating osteoarthritis in dogs. In conclusion, this thesis contributes to the growing body of knowledge on stem cell therapy as a promising treatment modality for osteoarthritis in dogs. By exploring the efficacy and safety of this innovative approach, this research seeks to improve the quality of life for dogs suffering from this debilitating joint disease and advance the field of veterinary regenerative medicine.

Thesis Overview

The project titled "Exploring the Use of Stem Cell Therapy in Treating Osteoarthritis in Dogs" delves into the innovative realm of veterinary medicine by investigating the potential of stem cell therapy in managing osteoarthritis, a common and debilitating condition affecting dogs. Osteoarthritis is characterized by progressive joint degeneration, leading to pain, inflammation, and reduced mobility in affected animals. Traditional treatment options for osteoarthritis in dogs often provide only symptomatic relief and do not address the underlying degenerative changes in the joint tissues. Stem cell therapy has emerged as a promising regenerative medicine approach that harnesses the regenerative potential of stem cells to promote tissue repair and regeneration. In the context of osteoarthritis, stem cell therapy aims to not only alleviate symptoms but also to repair damaged joint tissues and potentially slow down the progression of the disease. This research project aims to explore the efficacy of stem cell therapy in treating osteoarthritis in dogs through a comprehensive investigation that includes literature review, research methodology, data analysis, and interpretation. The project will delve into the mechanisms of action of stem cells in promoting tissue repair and modulating the inflammatory response within the arthritic joint. By conducting a thorough literature review, the project will synthesize existing knowledge on the use of stem cell therapy in veterinary medicine, specifically focusing on osteoarthritis in dogs. This will provide a solid foundation for understanding the current state of research, identifying gaps in knowledge, and formulating research questions to guide the study. The research methodology will involve designing and implementing a study protocol to evaluate the efficacy of stem cell therapy in a cohort of dogs diagnosed with osteoarthritis. This may include assessing clinical outcomes, such as pain relief, joint function, and quality of life, as well as conducting imaging studies to evaluate changes in joint structure and function following stem cell treatment. Data analysis and interpretation will be crucial steps in determining the effectiveness of stem cell therapy in treating osteoarthritis in dogs. Statistical analysis of the results obtained from the study will provide valuable insights into the potential benefits of stem cell therapy and its implications for clinical practice. Overall, this research project seeks to contribute to the growing body of knowledge on regenerative medicine in veterinary practice and advance the field of osteoarthritis management in dogs. By exploring the use of stem cell therapy as a novel treatment modality, this project aims to offer new perspectives and potential therapeutic options for improving the quality of life of dogs suffering from osteoarthritis.