Thesis Abstract

Abstract
Osteoarthritis is a common degenerative joint disease that affects dogs, causing pain and reduced mobility. Current treatment options provide only symptomatic relief, and there is a need for novel therapies to address the underlying pathophysiology of the disease. Stem cell therapy has emerged as a promising approach in regenerative medicine, offering the potential to repair damaged tissues and modulate the inflammatory response associated with osteoarthritis. This thesis aims to explore the use of stem cell therapy in treating osteoarthritis in dogs. Chapter one provides an introduction to the research, outlining the background of the study and the problem statement. The objectives of the study are to evaluate the efficacy of stem cell therapy in alleviating osteoarthritis symptoms in dogs and to investigate the mechanisms underlying its therapeutic effects. The limitations and scope of the study are discussed, along with the significance of the research. The chapter concludes with the structure of the thesis and definitions of key terms. Chapter two presents a comprehensive literature review covering ten key areas related to osteoarthritis in dogs and the use of stem cell therapy. This includes the pathophysiology of osteoarthritis, current treatment options, the biology of stem cells, previous studies on stem cell therapy in animal models, and the potential benefits and challenges of using stem cells in treating osteoarthritis. Chapter three details the research methodology, including the selection of study participants, stem cell isolation and characterization, treatment protocols, outcome measures, and statistical analysis methods. The chapter also discusses ethical considerations and potential risks associated with stem cell therapy in dogs. Chapter four presents the findings of the study, including the clinical outcomes of stem cell therapy in dogs with osteoarthritis, changes in inflammatory markers, histological analysis of joint tissues, and any adverse events observed during the study. The results are interpreted in the context of existing literature and implications for future research are discussed. Chapter five provides a conclusion and summary of the thesis, highlighting the key findings, their significance in the field of veterinary medicine, and recommendations for further research. The potential applications of stem cell therapy in clinical practice for treating osteoarthritis in dogs are discussed, along with considerations for translating research findings into practical therapies. In conclusion, this thesis contributes to the growing body of knowledge on the use of stem cell therapy in veterinary medicine and provides valuable insights into the potential benefits of this innovative approach in treating osteoarthritis in dogs. Further research is needed to optimize treatment protocols, establish long-term efficacy and safety profiles, and advance the field of regenerative medicine for companion animals.

Thesis Overview

Overview: Osteoarthritis is a common degenerative joint disease that affects dogs, leading to pain, stiffness, and reduced mobility. Current treatment options for osteoarthritis in dogs are limited and often focus on managing symptoms rather than addressing the underlying cause of the disease. In recent years, there has been growing interest in the use of stem cell therapy as a potential treatment for osteoarthritis in dogs. Stem cells have the unique ability to differentiate into various cell types, including cartilage cells, which could help regenerate damaged joint tissue and alleviate the symptoms of osteoarthritis. The aim of this research project is to explore the use of stem cell therapy in treating osteoarthritis in dogs. This study will investigate the efficacy and safety of stem cell therapy as a potential treatment option for dogs with osteoarthritis. By examining the existing literature on stem cell therapy in veterinary medicine and conducting experimental research, this project seeks to provide valuable insights into the application of stem cell therapy for osteoarthritis in dogs. The research will begin with a comprehensive literature review to establish the current state of knowledge on stem cell therapy for osteoarthritis in dogs. This review will cover key topics such as the biology of stem cells, the pathophysiology of osteoarthritis, and the mechanisms by which stem cell therapy may benefit dogs with osteoarthritis. By synthesizing existing research findings, this review will lay the foundation for the experimental phase of the study. The experimental phase of the research will involve conducting in vitro and in vivo studies to evaluate the potential of stem cell therapy in treating osteoarthritis in dogs. In vitro experiments will focus on assessing the ability of stem cells to differentiate into cartilage cells and repair damaged joint tissue. In vivo studies will involve administering stem cell therapy to dogs with osteoarthritis and monitoring their clinical outcomes over time. Parameters such as pain levels, joint mobility, and radiographic imaging will be used to assess the efficacy of stem cell therapy. The findings of this research project are expected to contribute valuable insights to the field of veterinary medicine and provide evidence-based recommendations for the use of stem cell therapy in treating osteoarthritis in dogs. By elucidating the mechanisms of action and potential benefits of stem cell therapy, this study has the potential to advance the development of innovative treatment strategies for osteoarthritis in dogs, ultimately improving the quality of life for canine patients suffering from this debilitating condition.