Thesis Abstract

Abstract
Osteoarthritis is a common degenerative joint disease affecting dogs of all ages and breeds, leading to chronic pain and reduced mobility. Current treatment options for osteoarthritis in dogs focus on managing symptoms rather than addressing the underlying cause of the disease. Stem cell therapy has emerged as a promising regenerative medicine approach that aims to promote tissue repair and regeneration. This thesis explores the use of stem cell therapy in the treatment of osteoarthritis in dogs, with a focus on its efficacy, safety, and potential mechanisms of action. The introduction provides an overview of osteoarthritis in dogs, highlighting the need for novel treatment strategies to improve the quality of life for affected animals. The background of the study discusses the pathophysiology of osteoarthritis and the role of stem cells in tissue repair and regeneration. The problem statement emphasizes the limitations of current treatment options and the potential benefits of stem cell therapy. The objectives of the study are to evaluate the efficacy of stem cell therapy in alleviating symptoms of osteoarthritis, assess the safety profile of this treatment modality, and investigate the mechanisms underlying its therapeutic effects. The literature review synthesizes existing research on stem cell therapy for osteoarthritis in dogs, covering topics such as stem cell sources, delivery methods, and outcomes of clinical trials. The research methodology outlines the experimental design, including sample size calculation, treatment protocol, outcome measures, and statistical analysis plan. Data collection methods, including clinical assessments, imaging studies, and laboratory analysis, are detailed to ensure comprehensive evaluation of treatment outcomes. The discussion of findings presents the results of the study, including changes in lameness scores, joint mobility, and radiographic evidence of disease progression. The potential mechanisms of action of stem cell therapy, such as anti-inflammatory and immunomodulatory effects, are explored to provide insights into the therapeutic benefits observed in treated dogs. The implications of these findings for veterinary practice and future research directions are discussed to guide the translation of stem cell therapy from the laboratory to clinical settings. In conclusion, this thesis demonstrates the potential of stem cell therapy as a novel treatment approach for osteoarthritis in dogs. The safety and efficacy of this treatment modality support its use as a regenerative medicine option to improve the quality of life for dogs suffering from this debilitating condition. Further research is warranted to optimize treatment protocols, address potential challenges, and expand the application of stem cell therapy in veterinary medicine.

Thesis Overview

The project titled "Exploring the Use of Stem Cell Therapy in the Treatment of Osteoarthritis in Dogs" aims to investigate the potential benefits and effectiveness of utilizing stem cell therapy as a treatment option for osteoarthritis in dogs. Osteoarthritis is a common degenerative joint disease in dogs, leading to pain, stiffness, and decreased mobility. Traditional treatment methods such as pain management and anti-inflammatory medications may provide symptomatic relief but do not address the underlying cause of the disease. Stem cell therapy has emerged as a promising regenerative medicine approach that harnesses the regenerative potential of stem cells to repair and regenerate damaged tissues. In the context of osteoarthritis, stem cell therapy offers the potential to promote cartilage repair, reduce inflammation, and improve joint function in affected dogs. This project seeks to explore the mechanisms by which stem cell therapy exerts its therapeutic effects in the context of osteoarthritis, as well as to evaluate its safety and efficacy in canine patients. The research will involve a comprehensive literature review to gather existing knowledge on the use of stem cell therapy for osteoarthritis in dogs, including relevant studies on the mechanisms of action, treatment protocols, and clinical outcomes. Additionally, the project will include experimental studies or clinical trials to assess the impact of stem cell therapy on disease progression, pain levels, joint function, and quality of life in dogs with osteoarthritis. Key aspects to be investigated in this project include the optimal source of stem cells for therapy, the most effective delivery methods, the ideal dosing regimens, and the long-term safety and durability of treatment effects. By elucidating these factors, the research aims to provide valuable insights into the potential of stem cell therapy as a novel and effective treatment modality for osteoarthritis in dogs. Ultimately, the findings of this project have the potential to significantly advance our understanding of stem cell therapy in the context of osteoarthritis treatment for dogs. The results may have important implications for veterinary medicine, offering new avenues for the management of osteoarthritis and potentially improving the quality of life for canine patients suffering from this debilitating condition.