Thesis Abstract

Abstract
Osteoarthritis is a common degenerative joint disease that affects dogs, leading to pain, decreased mobility, and reduced quality of life. Traditional treatment options for osteoarthritis in dogs often provide only symptomatic relief and do not address the underlying cause of the disease. Stem cell therapy has emerged as a promising alternative for the treatment of osteoarthritis, offering the potential for tissue repair and regeneration. This thesis explores the use of stem cell therapy in the treatment of osteoarthritis in dogs, aiming to evaluate its efficacy, safety, and long-term outcomes. The introductory chapter provides a comprehensive overview of the background of the study, including the prevalence and impact of osteoarthritis in dogs, the limitations of current treatment modalities, and the scope and significance of utilizing stem cell therapy as a novel approach. The chapter also outlines the objectives of the study and defines key terminologies to establish a solid foundation for the research. Chapter two presents a thorough literature review of existing studies and research on stem cell therapy for osteoarthritis in both humans and animals. The review covers various aspects such as the mechanisms of action of stem cells, the types of stem cells used in therapy, the routes of administration, and the reported outcomes and challenges associated with stem cell treatment for osteoarthritis in dogs. Chapter three details the research methodology employed in this study, including the selection criteria for the canine subjects, the source and preparation of stem cells, the treatment protocols, and the assessment parameters used to evaluate the efficacy and safety of stem cell therapy. The chapter also discusses ethical considerations and potential biases that may influence the results of the study. Chapter four presents a comprehensive discussion of the findings obtained from the study, including the clinical outcomes, the histological changes in the affected joints, the adverse events observed, and the overall impact of stem cell therapy on the management of osteoarthritis in dogs. The chapter also compares these findings with existing literature and highlights any novel contributions or discrepancies identified in this study. Finally, chapter five offers a conclusive summary of the research findings, emphasizing the potential of stem cell therapy as a viable treatment option for osteoarthritis in dogs. The chapter discusses the implications of the study results for clinical practice, research directions for future studies, and the broader impact of stem cell therapy on veterinary medicine and animal welfare. Overall, this thesis provides valuable insights into the role of stem cell therapy in advancing the treatment of osteoarthritis in dogs and underscores the importance of further research in this field.

Thesis Overview

The research project titled "Exploring the Use of Stem Cell Therapy in the Treatment of Osteoarthritis in Dogs" aims to investigate the potential of stem cell therapy as a novel approach for treating osteoarthritis in dogs. Osteoarthritis, a common degenerative joint disease in dogs, can cause pain, lameness, and decreased mobility, significantly affecting their quality of life. Current treatment options for osteoarthritis in dogs are often limited to pain management and anti-inflammatory medications, which may not address the underlying cause of the disease. Stem cell therapy holds promise as a regenerative medicine approach that could potentially repair damaged tissues and promote healing in arthritic joints. By exploring the use of stem cells in the treatment of osteoarthritis in dogs, this research aims to contribute to the development of more effective and long-lasting treatment options for this debilitating condition. The research will involve a comprehensive literature review to examine existing studies on stem cell therapy for osteoarthritis in dogs, including the mechanisms of action, efficacy, safety, and potential limitations of this treatment approach. Additionally, the research will explore the different types of stem cells that have been used in previous studies, such as mesenchymal stem cells, and their therapeutic potential in the context of osteoarthritis. Furthermore, the research methodology will include in vitro and in vivo experiments to investigate the effects of stem cell therapy on cartilage regeneration, inflammation reduction, and pain relief in a canine model of osteoarthritis. The study will assess key outcome measures such as joint function, pain scores, histological changes in the joint tissues, and the expression of inflammatory markers to evaluate the therapeutic potential of stem cell therapy. The findings of this research are expected to provide valuable insights into the feasibility and efficacy of stem cell therapy for treating osteoarthritis in dogs. By elucidating the mechanisms of action and potential benefits of stem cell therapy in canine osteoarthritis, this research aims to pave the way for the development of innovative and personalized treatment strategies that could improve the quality of life for dogs suffering from this debilitating condition.