Thesis Abstract

Abstract
Canine osteoarthritis (OA) is a common degenerative joint disease that affects millions of dogs worldwide, leading to pain, reduced mobility, and decreased quality of life. Current treatment options for OA are limited and often focus on managing symptoms rather than addressing the underlying cause of the disease. Stem cell therapy has emerged as a promising regenerative medicine approach that aims to repair damaged tissues and promote healing. This thesis presents a comprehensive exploration of the use of stem cell therapy in the treatment of canine OA. The introduction provides an overview of the background of the study, highlighting the prevalence and impact of OA in dogs. The problem statement underscores the limitations of current treatment modalities and the need for innovative therapeutic strategies. The objectives of the study are outlined to evaluate the efficacy and safety of stem cell therapy in canine OA, while the limitations and scope of the study are delineated to provide a clear understanding of the research boundaries. The significance of the study lies in its potential to advance veterinary medicine by introducing a novel therapeutic approach for managing OA in dogs. Chapter two consists of a detailed literature review that synthesizes existing research on stem cell therapy, canine OA pathophysiology, and current treatment modalities. The review encompasses ten key areas, including the mechanisms of action of stem cells, preclinical and clinical studies on stem cell therapy in veterinary medicine, and the challenges and opportunities associated with translating stem cell research into clinical practice. Chapter three delineates the research methodology, detailing the study design, sample selection criteria, stem cell isolation and characterization protocols, treatment administration techniques, outcome measures, and statistical analysis methods. The chapter also addresses ethical considerations and regulatory requirements governing the use of stem cell therapy in veterinary clinical trials. Chapter four presents a comprehensive discussion of the study findings, including the efficacy of stem cell therapy in reducing pain, improving joint function, and promoting tissue regeneration in dogs with OA. The results are contextualized within the broader landscape of regenerative medicine and offer insights into the potential mechanisms underlying the therapeutic effects of stem cells in OA. Finally, chapter five offers a succinct conclusion and summary of the thesis, highlighting the key findings, implications for veterinary practice, and recommendations for future research directions. Overall, this thesis contributes to the growing body of evidence supporting the use of stem cell therapy as a promising treatment modality for canine OA, with the potential to revolutionize the management of this debilitating disease in dogs.

Thesis Overview