Thesis Abstract

The rise of multidrug-resistant bacteria poses a significant threat to public health, emphasizing the urgent need for alternative antimicrobial agents. This research project focuses on investigating the antimicrobial potential of natural plant extracts against multidrug-resistant bacteria. The study aims to explore the efficacy of selected plant extracts in inhibiting the growth of various multidrug-resistant bacterial strains, potentially providing new avenues for combating antibiotic resistance. The research methodology involves the extraction of bioactive compounds from selected plant species known for their traditional medicinal uses. These plant extracts will be screened for antimicrobial activity using well-established methods such as disc diffusion and broth microdilution assays. Furthermore, the potential synergistic effects of combining different plant extracts will also be investigated to enhance antimicrobial efficacy. The literature review delves into previous studies on natural plant extracts with antimicrobial properties, highlighting the diverse range of bioactive compounds found in plants and their mechanisms of action against bacteria. This review provides a comprehensive background to support the rationale for the current research study. The findings from this research project will be discussed in detail, focusing on the antimicrobial activity of specific plant extracts against multidrug-resistant bacterial strains. The results will be analyzed to determine the potency and spectrum of activity of the plant extracts, as well as any potential mechanisms of action involved in inhibiting bacterial growth. In conclusion, this thesis project aims to contribute valuable insights into the antimicrobial potential of natural plant extracts as alternative agents against multidrug-resistant bacteria. The significance of this research lies in the potential discovery of novel antimicrobial compounds from plant sources, offering promising options for combating antibiotic resistance and improving public health outcomes.

Thesis Overview

The project titled "Investigation of the antimicrobial potential of natural plant extracts against multidrug-resistant bacteria" aims to explore the effectiveness of natural plant extracts in combating multidrug-resistant bacteria. With the increasing prevalence of multidrug-resistant bacterial infections posing a significant threat to public health, there is a pressing need to identify alternative antimicrobial agents to combat these resistant strains. The research will focus on investigating the antimicrobial properties of selected natural plant extracts known for their traditional medicinal uses. These plant extracts will be obtained from a variety of plant species known for their antimicrobial properties and will be subjected to rigorous testing to evaluate their effectiveness against multidrug-resistant bacteria strains. The study will involve conducting a series of laboratory experiments to assess the antibacterial activity of the plant extracts through methods such as agar well diffusion assay, minimum inhibitory concentration (MIC) determination, and time-kill kinetic studies. The goal is to determine the potency of the plant extracts in inhibiting the growth of multidrug-resistant bacteria and potentially identifying new sources of antimicrobial agents. Furthermore, the research will involve investigating the underlying mechanisms of action of the plant extracts against multidrug-resistant bacteria. This will include exploring the potential synergistic effects of combining different plant extracts and elucidating the biochemical pathways through which the plant compounds exert their antimicrobial effects. Overall, this project aims to contribute valuable insights into the antimicrobial potential of natural plant extracts as a promising alternative to conventional antibiotics in the fight against multidrug-resistant bacteria. The findings from this research have the potential to inform the development of novel antimicrobial agents derived from natural sources, thereby offering new strategies to combat the growing threat of multidrug-resistant bacterial infections.