Thesis Abstract

Abstract
Antibiotic resistance poses a significant threat to global public health, leading to an urgent need for alternative strategies to combat multidrug-resistant bacteria. Bacteriophages, viruses that infect and replicate within bacteria, have emerged as a promising tool in the fight against antibiotic-resistant bacteria. This thesis explores the role of bacteriophages in controlling antibiotic-resistant bacteria, focusing on their potential as a novel therapeutic approach. The introduction provides background information on antibiotic resistance, highlighting the escalating challenge it presents to healthcare systems worldwide. The problem statement underscores the urgent need for innovative solutions to address antibiotic resistance, setting the stage for the research objectives to investigate the efficacy of bacteriophages in combating multidrug-resistant bacteria. The literature review delves into ten key studies that have explored the use of bacteriophages as antibacterial agents, highlighting their mechanisms of action, advantages, and limitations. The research methodology section outlines the experimental design and procedures used to evaluate the effectiveness of bacteriophages against antibiotic-resistant bacteria, including in vitro and in vivo studies. The findings discussed in Chapter Four reveal the potential of bacteriophages to target and eliminate antibiotic-resistant bacterial strains effectively. The results demonstrate the ability of bacteriophages to overcome bacterial resistance mechanisms and provide a sustainable alternative to traditional antibiotics. In conclusion, this thesis emphasizes the significant role that bacteriophages can play in controlling antibiotic-resistant bacteria. The findings underscore the importance of further research and clinical trials to harness the full potential of bacteriophages as a viable therapeutic option. The implications of this study are far-reaching, offering new insights into combating antibiotic resistance and improving patient outcomes in the era of multidrug-resistant infections.

Thesis Overview

The project titled "Exploring the role of bacteriophages in controlling antibiotic-resistant bacteria" aims to investigate the potential of bacteriophages as a promising alternative to combat antibiotic-resistant bacteria. Antibiotic resistance poses a significant threat to public health globally, leading to increased morbidity, mortality, and healthcare costs. Traditional antibiotics are becoming less effective due to the emergence and spread of resistant bacterial strains, necessitating the search for novel antimicrobial strategies. Bacteriophages, or phages, are viruses that specifically infect and replicate within bacteria. They have been recognized as natural predators of bacteria and have the ability to lyse bacterial cells, making them a potential tool for controlling bacterial infections, particularly those caused by antibiotic-resistant strains. This research project seeks to explore the effectiveness of bacteriophages in targeting and eradicating antibiotic-resistant bacteria, with the ultimate goal of developing phage-based therapies as an alternative or adjunct to traditional antibiotics. The research will involve a comprehensive literature review to explore the existing knowledge on bacteriophages, antibiotic resistance mechanisms, and the interactions between phages and bacteria. This review will provide a theoretical framework for understanding the potential of phage therapy in combating antibiotic resistance. Furthermore, the project will include experimental studies to evaluate the efficacy of bacteriophages against a panel of antibiotic-resistant bacterial strains. The research methodology will involve isolating and characterizing phages, testing their lytic activity against target bacteria in vitro, and assessing their potential for in vivo applications using animal models of infection. The findings of this study are expected to contribute valuable insights into the use of bacteriophages as a novel approach to combat antibiotic-resistant bacteria. By elucidating the mechanisms of phage-bacteria interactions and evaluating the therapeutic potential of phage therapy, this research aims to address the urgent need for alternative strategies to tackle the growing threat of antibiotic resistance. Overall, this research project on exploring the role of bacteriophages in controlling antibiotic-resistant bacteria holds significant promise for advancing our understanding of phage biology and its application in combating drug-resistant bacterial infections. It is hoped that the outcomes of this study will pave the way for the development of innovative phage-based therapies that can complement existing antibiotic treatments and help mitigate the global crisis of antibiotic resistance.