Thesis Abstract

The escalating issue of multi-drug resistant bacteria poses a significant threat to public health globally, necessitating the exploration of alternative antimicrobial agents. This study investigates the antimicrobial activity of plant extracts against multi-drug resistant bacteria to identify potential natural sources of novel antimicrobial compounds. The research methodology involved the extraction of bioactive compounds from selected plants, followed by screening for antimicrobial activity against a panel of multi-drug resistant bacterial strains using standardized methods. The results revealed varying degrees of antimicrobial activity among the plant extracts, with some demonstrating potent inhibitory effects against the multi-drug resistant bacteria tested. Through a comprehensive discussion of the findings, this thesis elucidates the potential of plant extracts as alternative antimicrobial agents and highlights the importance of further research in this area. The study contributes to the growing body of knowledge on natural antimicrobial compounds and underscores the significance of exploring plant-derived sources for combating multi-drug resistant bacteria. The findings of this research have implications for the development of new antimicrobial agents and the potential integration of plant extracts in the fight against antibiotic resistance.

Thesis Overview

The project titled "Investigation of the antimicrobial activity of plant extracts against multi-drug resistant bacteria" aims to explore the potential of plant extracts as alternative antimicrobial agents against bacteria that have developed resistance to multiple conventional antibiotics. This research is crucial due to the increasing global concern over the rise of multi-drug resistant bacteria, which poses a significant threat to public health by limiting treatment options for infectious diseases. The study will involve screening a variety of plant extracts for their antimicrobial properties using standardized laboratory methods. The research will focus on identifying plant species known for their traditional medicinal uses and potential antimicrobial properties. Various extraction methods will be employed to isolate bioactive compounds from these plants, which will then be tested against a panel of multi-drug resistant bacterial strains commonly found in clinical settings. The project will also investigate the mechanisms of action of the bioactive compounds present in the plant extracts against multi-drug resistant bacteria. This will involve assessing the impact of these compounds on bacterial cell membranes, protein synthesis, and other essential cellular processes. Understanding the mode of action of these plant-derived antimicrobial agents is essential for developing effective treatment strategies and combating antibiotic resistance. Furthermore, the research will evaluate the potential synergistic effects of combining plant extracts with conventional antibiotics to enhance their antimicrobial activity against multi-drug resistant bacteria. This approach may offer a promising solution to overcome antibiotic resistance by improving the efficacy of existing antibiotics through combination therapy with plant-derived compounds. Overall, the project "Investigation of the antimicrobial activity of plant extracts against multi-drug resistant bacteria" aims to contribute valuable insights into the development of alternative antimicrobial agents from natural sources. The findings of this research have the potential to inform the development of novel antimicrobial therapies and address the growing challenge of antibiotic resistance in the field of microbiology and public health.