Thesis Abstract

Abstract
The emergence and spread of antibiotic-resistant bacteria pose a significant threat to public health worldwide. In response to this challenge, alternative therapeutic strategies are being explored, including the use of bacteriophages to target and control antibiotic-resistant bacteria. Bacteriophages are viruses that specifically infect and replicate within bacterial cells, offering a promising approach to combatting antibiotic resistance. This thesis investigates the role of bacteriophages in controlling antibiotic-resistant bacteria in clinical settings. Chapter 1 provides an introduction to the topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. The literature review in Chapter 2 explores ten key studies on the use of bacteriophages to target antibiotic-resistant bacteria, highlighting the efficacy and limitations of this approach. Chapter 3 details the research methodology, including the selection of bacteriophages, bacterial strains, experimental design, and data analysis methods. The methodology also covers the assessment of bacteriophage activity against antibiotic-resistant bacteria in vitro and in vivo. Chapter 4 presents a comprehensive discussion of the findings, analyzing the effectiveness of bacteriophages in controlling antibiotic-resistant bacteria in clinical settings. The chapter examines factors influencing bacteriophage efficacy, such as host range, resistance mechanisms, and phage-bacteria interactions. In Chapter 5, the conclusion and summary of the thesis are provided, highlighting the key findings and implications of the research. The study demonstrates the potential of bacteriophages as a viable alternative or adjunct to antibiotics in combating antibiotic-resistant bacteria in clinical settings. Future research directions and challenges in the field are also discussed. Overall, this thesis contributes to the growing body of knowledge on the use of bacteriophages as a promising strategy for addressing antibiotic resistance in clinical practice. By harnessing the specificity and efficacy of bacteriophages, innovative approaches can be developed to combat the rise of antibiotic-resistant bacteria and improve patient outcomes in healthcare settings.

Thesis Overview

The project titled "The role of bacteriophages in controlling antibiotic-resistant bacteria in clinical settings" aims to explore the potential of bacteriophages as a promising alternative to conventional antibiotics in combating the growing threat of antibiotic-resistant bacteria. Antibiotic resistance has become a major global health concern, leading to increased mortality rates, prolonged hospital stays, and higher healthcare costs. Bacteriophages, or viruses that infect and kill bacteria, have gained attention as a possible solution due to their specificity, effectiveness, and ability to overcome bacterial resistance mechanisms. The research will begin with a comprehensive literature review to examine the current state of antibiotic resistance, the mechanisms underlying bacteriophage-bacteria interactions, and previous studies on the use of bacteriophages in clinical settings. This review will provide a solid foundation for understanding the significance of bacteriophages in combating antibiotic resistance. The methodology section will outline the experimental approaches and techniques that will be employed to investigate the efficacy of bacteriophages against antibiotic-resistant bacteria. This will include in vitro studies to assess the lytic activity of bacteriophages, in vivo experiments to evaluate their therapeutic potential in animal models, and molecular analyses to understand the mechanisms of bacteriophage action. The findings from the study will be discussed in detail in the results and discussion section, highlighting the effectiveness of bacteriophages in controlling antibiotic-resistant bacteria and comparing their performance with traditional antibiotics. The implications of these findings for clinical practice and future research directions will also be explored. In conclusion, this research project seeks to shed light on the role of bacteriophages as a viable alternative to antibiotics for combating antibiotic-resistant bacteria in clinical settings. By elucidating the mechanisms of bacteriophage action and evaluating their therapeutic potential, this study aims to contribute to the development of novel strategies for addressing the global challenge of antibiotic resistance.