Thesis Abstract

<p> </p><p>The susceptibilities of Salmonella typhi and other pathogens to antibiotics and hot aqueous extract of <em>Hibiscus sabdariffa</em>&nbsp;were investigated using agar diffusion and agar well diffusion methods respectively. <em>Salmonella typhi</em>&nbsp;was sensitive to ampicillin, cetriaxone, ciprofloxacin, gentamycin of ofloxacin and perfloxacin. Nitrofurantoin, ampicillin, clarithomycin and augumentin are resistant. <em>Escherichia coli, Klebsiella spp,</em>&nbsp;and <em>Staphylococcus aureus</em>&nbsp;were sensitive to 50%, 70% and 60% of the antibiotics respectively.</p><p><em>Pseudomonas aeruginosa </em>was resistant to all antibiotics.<em>&nbsp;Hibiscus sabdariffa </em>extract (0.6g in 6ml of sterile distilled water) was active against <em>S. typhi</em>&nbsp;at concentrations of 100mg/ml, 50mg/ml and 25mg/ml (inhibitions zone diameter IZDs = 23mm, 20mm and 16mm respectively). <em>Staphylococcus aureus</em>&nbsp;was susceptible to 100mg/ml, 50mg/ml, 25mg/ml and 12.5mg/ml of the extract with IZDs of 29mm, 18mm, 17mm and 14mm respectively. <em>Klebsiella spp</em>&nbsp;was susceptible to concentrations of 25mg/ml and 12.5mg/ml of the extract with IZDs of 15mm and 10mm respectively. <em>Escherichia coli</em>&nbsp;and <em>Pseudomonas</em><em>aeruginosa </em>were resistant to all the concentrations of<em>&nbsp;H. sabdariffa </em>extract. It is therefore imperative to note that the use of medicinal plants is recommended to the Government and Industry</p> <br><p></p>

Thesis Overview