Thesis Abstract

Abstract
The prevalence of Type 2 diabetes has been on the rise globally, presenting a significant public health concern. In recent years, there has been growing interest in the potential role of probiotics in improving metabolic health, particularly in individuals with Type 2 diabetes. This thesis investigates the effect of probiotics supplementation on gut microbiota composition and metabolic health in adults with Type 2 diabetes. Chapter One provides an introduction to the study, outlining the background, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. The rising prevalence of Type 2 diabetes and the potential of probiotics to modulate gut microbiota for metabolic benefits form the basis for this research. Chapter Two presents a comprehensive literature review encompassing ten key aspects related to probiotics, gut microbiota, Type 2 diabetes, and metabolic health. The review synthesizes existing knowledge on the mechanisms through which probiotics influence gut microbiota composition and metabolic health in individuals with Type 2 diabetes. Chapter Three details the research methodology employed in this study. It includes information on the study design, participant recruitment criteria, probiotics intervention protocol, data collection methods, gut microbiota analysis techniques, metabolic health assessments, statistical analyses, ethical considerations, and potential biases. Chapter Four presents a detailed discussion of the findings obtained from the study. The impact of probiotics supplementation on gut microbiota composition, metabolic parameters (such as blood glucose levels, insulin sensitivity, lipid profile), and inflammatory markers in adults with Type 2 diabetes is thoroughly analyzed and interpreted. Chapter Five concludes the thesis by summarizing the key findings, discussing the implications of the results for clinical practice and future research directions. The study contributes to the growing body of evidence supporting the potential of probiotics as an adjunct therapy for improving metabolic health in individuals with Type 2 diabetes. In conclusion, this thesis sheds light on the promising role of probiotics in modulating gut microbiota composition and enhancing metabolic health in adults with Type 2 diabetes. The findings underscore the importance of further research in this area to elucidate the mechanisms involved and optimize probiotics interventions for better management of Type 2 diabetes and related metabolic disorders.

Thesis Overview

The research project titled "Effect of Probiotics Supplementation on Gut Microbiota Composition and Metabolic Health in Adults with Type 2 Diabetes" aims to investigate the potential benefits of probiotics supplementation in improving gut microbiota composition and metabolic health in adults diagnosed with Type 2 Diabetes. This study is essential due to the increasing prevalence of Type 2 Diabetes globally and the emerging evidence suggesting a link between gut microbiota dysbiosis and metabolic disorders. The project will begin by providing a comprehensive introduction to the topic, highlighting the background of the study and the problem statement that underpins the research. The objectives of the study will be clearly outlined, focusing on assessing the impact of probiotics supplementation on gut microbiota diversity, metabolic parameters, and overall health outcomes in individuals with Type 2 Diabetes. The research methodology section will detail the experimental design, participant recruitment criteria, probiotics intervention protocol, data collection methods, and statistical analysis plan. This chapter will also discuss ethical considerations and potential limitations of the study that may impact the interpretation of results. The literature review section will critically evaluate existing research on the role of gut microbiota in metabolic health and the effects of probiotics supplementation on various health conditions, including Type 2 Diabetes. This chapter will provide a theoretical framework for the study and identify gaps in current knowledge that the research aims to address. The discussion of findings chapter will present and analyze the results obtained from the study, focusing on changes in gut microbiota composition, metabolic parameters such as blood glucose levels and insulin sensitivity, and any observed improvements in overall health outcomes in participants receiving probiotics supplementation. Finally, the conclusion and summary chapter will summarize the key findings of the study, discuss their implications for clinical practice and future research, and offer recommendations for individuals with Type 2 Diabetes considering probiotics supplementation as a potential adjunct therapy to improve metabolic health. Overall, this research project seeks to contribute to the growing body of knowledge on the role of probiotics in modulating gut microbiota composition and metabolic health in individuals with Type 2 Diabetes, with the ultimate goal of providing evidence-based recommendations for improving the management and treatment of this prevalent chronic condition.