Thesis Abstract

Abstract
The prevalence of overweight and obesity continues to rise globally, posing significant health challenges. In recent years, research has increasingly focused on the role of gut microbiota in weight management and overall health. Probiotics, live microorganisms that confer health benefits when consumed in adequate amounts, have gained attention for their potential impact on gut microbiota composition and weight regulation. This thesis investigates the effect of probiotics supplementation on gut microbiota composition and weight management in overweight individuals. Chapter 1 provides an introduction to the study, presenting the background, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. Chapter 2 comprises a comprehensive literature review covering ten key aspects related to gut microbiota, probiotics, weight management, and their interplay. Chapter 3 details the research methodology, including study design, participant selection criteria, probiotics intervention protocol, data collection methods, and statistical analysis plan. Chapter 4 presents an in-depth discussion of the findings, analyzing the impact of probiotics supplementation on gut microbiota composition and weight management outcomes in overweight individuals. Various factors influencing the effectiveness of probiotics in modulating gut microbiota and promoting weight loss are explored, shedding light on potential mechanisms underlying these effects. The implications of the study results for future research and clinical practice are also discussed. In Chapter 5, the conclusion and summary of the thesis are provided, highlighting the key findings, implications, and limitations of the study. The overall impact of probiotics supplementation on gut microbiota composition and weight management in overweight individuals is synthesized, emphasizing the potential benefits and challenges associated with this intervention. Recommendations for future research directions and practical applications are proposed to further elucidate the role of probiotics in promoting healthy weight and gut microbiota balance. This thesis contributes to the growing body of knowledge on the relationship between probiotics, gut microbiota, and weight management, offering valuable insights into potential strategies for addressing the global burden of overweight and obesity. By elucidating the mechanisms by which probiotics influence gut microbiota composition and weight regulation, this study provides a foundation for further research and the development of evidence-based interventions to support optimal health outcomes in overweight individuals.

Thesis Overview

The project titled "Effect of Probiotics Supplementation on Gut Microbiota Composition and Weight Management in Overweight Individuals" aims to investigate the impact of probiotic supplementation on the gut microbiota composition and weight management in individuals who are overweight. Probiotics are live microorganisms that are believed to confer health benefits when consumed in adequate amounts. The gut microbiota plays a crucial role in various physiological processes, including metabolism and immune function. The study will delve into the existing literature on probiotics, gut microbiota composition, and weight management to establish a theoretical framework for the research. It will explore the mechanisms through which probiotics may influence the gut microbiota and subsequently impact weight regulation in overweight individuals. By conducting a comprehensive literature review, the project seeks to identify gaps in current knowledge and propose novel insights into the potential role of probiotics in weight management. The research methodology will involve designing a randomized controlled trial to assess the effects of probiotic supplementation on gut microbiota composition and weight-related outcomes in overweight participants. This will include analyzing changes in gut microbiota diversity and abundance, as well as monitoring changes in body weight, body composition, and metabolic parameters over a specified intervention period. The study will also consider factors such as diet and physical activity levels to account for potential confounders. Data analysis will involve statistical methods to evaluate the impact of probiotic supplementation on gut microbiota composition and weight management outcomes. The findings of the study will be discussed in detail, highlighting any significant associations between probiotic intervention, gut microbiota changes, and weight-related parameters. Moreover, the implications of the results for clinical practice and future research will be considered. Overall, this research project aims to contribute valuable insights into the potential benefits of probiotics in modulating gut microbiota composition and aiding in weight management among overweight individuals. By elucidating the underlying mechanisms and effects of probiotics on the gut microbiota, this study seeks to advance our understanding of how probiotic supplementation may be utilized as a therapeutic approach for weight management in the context of obesity and related metabolic disorders.