Anaemia

 

Table Of Contents


Chapter ONE

1.0     Introduction

1.1     Anaemia

1.1.1 Biochemistry

1.2     Iron therapy

1.3     Biosynthesis of Heme

Chapter TWO

2.0     Classification

2.1     Hyporegenerative

2.1.1 Aplastic

2.1.2 Pure red cell aplasia (PRCA)

2.1.3 related to the myelodysplastic syndrome

2.1.4 Deficiency

2.1.5 Bone marrow infiltration and fibrosis

2.1.6 chronic disease (ACD)

2.1.7 chronic renal failure

2.2     Regenerative

2.2.1 Immune haemolytic

2.2.2 Sickle cell

2.2.3 due to enzymopathies and red cell membrane defects

2.2.4 Haemorrhagic

Chapter THREE

3.0     Selected

3.1     Pure red cell aplasia

3.2     B12 deficiency

3.3     Immune haemolytic

3.3.1 Classification

3.3.2 Pathophysiology of immune haemolytic

3.3.3 Diagnosis of haemolytic

3.4     Non-immune haemolytic

3.4.1 Paroxysmal nocturnal haemoglobinuria (PNH)

3.4.2 Microangiopathic disorders

3.4.3 Haemolysis secondary to toxic agents and other causes

Chapter FOUR

4.0     Conclusion

References


Thesis Abstract

Abstract
Anaemia is a common blood disorder that affects a large portion of the global population, with significant impact on public health. The condition is characterized by a decrease in the number of red blood cells or a decrease in the amount of hemoglobin in the blood, leading to reduced oxygen-carrying capacity. Anaemia can result from various causes including nutritional deficiencies, chronic diseases, genetic factors, and certain medications. The prevalence of anaemia varies across different regions and populations, with higher rates reported in developing countries, children, pregnant women, and the elderly. The consequences of anaemia can be severe, ranging from fatigue and weakness to impaired cognitive function and increased morbidity and mortality. Therefore, timely diagnosis and appropriate management of anaemia are crucial to prevent complications and improve quality of life. Diagnostic tests for anaemia typically involve measuring the levels of hemoglobin, hematocrit, and red blood cells in the blood. Additional tests may be required to determine the underlying cause of the condition. Treatment strategies for anaemia depend on the specific cause and may include dietary changes, iron supplementation, blood transfusions, or addressing the underlying medical condition. Preventive measures play a key role in reducing the burden of anaemia, particularly in high-risk populations. Promoting a healthy and balanced diet rich in iron, folate, and vitamin B12 is essential for preventing nutritional deficiencies that can lead to anaemia. In addition, public health interventions such as fortification of food products and supplementation programs can help address anaemia at a population level. Research efforts are ongoing to improve our understanding of the pathophysiology of anaemia and to develop novel treatment approaches. Advances in medical technology and genetic research hold promise for more personalized and effective management of anaemia in the future. Furthermore, raising awareness about the importance of early detection and treatment of anaemia is crucial for reducing its global burden and improving health outcomes. In conclusion, anaemia is a significant public health concern that requires a comprehensive approach involving healthcare providers, policymakers, researchers, and the community. By implementing preventive strategies, enhancing diagnostic capabilities, and exploring innovative treatment options, we can work towards reducing the prevalence and impact of anaemia on individuals and populations worldwide.

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