Thesis Abstract

Abstract
The development of novel drug delivery systems for targeted cancer therapy represents a promising approach to improve the efficacy and reduce the side effects of anticancer drugs. This thesis explores the design, development, and evaluation of innovative drug delivery systems tailored for targeted cancer treatment. The study focuses on addressing the limitations of current cancer therapies by enhancing drug delivery specificity, reducing systemic toxicity, and improving overall therapeutic outcomes. Chapter One provides an introduction to the research topic, highlighting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. The rationale for developing novel drug delivery systems for targeted cancer therapy is discussed, emphasizing the need for more effective and less toxic treatment options. Chapter Two presents a comprehensive literature review that covers ten key aspects related to drug delivery systems in cancer therapy. This includes an overview of current challenges in cancer treatment, the principles of targeted drug delivery, different types of drug delivery systems, mechanisms of drug targeting, and recent advancements in the field. The review synthesizes existing knowledge and identifies gaps that this research aims to address. Chapter Three outlines the research methodology employed in this study, detailing the experimental design, materials and methods, data collection procedures, and analytical techniques used to evaluate the performance of novel drug delivery systems. The chapter covers eight main components, including the selection of drug candidates, formulation development, in vitro and in vivo studies, characterization techniques, and statistical analysis of results. Chapter Four presents a detailed discussion of the findings obtained from the experimental studies conducted in this research. The chapter examines the efficacy, specificity, and safety profiles of the developed drug delivery systems in delivering anticancer agents to target cancer cells. It analyzes the results in relation to the research objectives and discusses the implications of the findings for future applications in cancer therapy. Chapter Five concludes the thesis by summarizing the key findings, discussing the implications for the field of cancer therapy, and proposing recommendations for further research and development. The study contributes to the advancement of targeted cancer therapy by introducing novel drug delivery systems that have the potential to improve treatment outcomes and quality of life for cancer patients. In conclusion, the "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" thesis presents a comprehensive investigation into the design and evaluation of innovative drug delivery systems for improved cancer treatment. The research findings offer valuable insights into the development of targeted drug delivery strategies and pave the way for future advancements in personalized cancer therapy.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the pressing need for more effective and targeted treatment options for cancer patients. Cancer remains one of the leading causes of mortality worldwide, with conventional cancer treatments often associated with significant side effects and limited efficacy. The development of novel drug delivery systems offers a promising approach to improve the therapeutic outcomes of cancer treatment by enhancing drug delivery to the tumor site while minimizing systemic toxicity. This research project will focus on the design, development, and evaluation of innovative drug delivery systems specifically tailored for targeted cancer therapy. The project will involve the synthesis and characterization of novel drug carriers, such as nanoparticles, liposomes, micelles, or dendrimers, which can encapsulate and deliver anti-cancer drugs to the tumor site with increased precision and efficiency. The research will also explore the incorporation of targeting ligands, such as antibodies, peptides, or aptamers, onto the surface of the drug delivery systems to enable specific recognition and binding to cancer cells, thereby enhancing drug uptake and therapeutic efficacy. In addition, the project will investigate the use of stimuli-responsive drug delivery systems that can release the encapsulated drugs in response to specific triggers present in the tumor microenvironment, such as pH, temperature, or enzyme levels. Furthermore, the project will involve in vitro and in vivo studies to evaluate the performance and therapeutic potential of the developed drug delivery systems. Cell culture experiments will assess the cellular uptake, cytotoxicity, and anti-cancer activity of the drug-loaded carriers using various cancer cell lines. Animal studies will be conducted to investigate the biodistribution, pharmacokinetics, and tumor targeting capability of the drug delivery systems in vivo. The ultimate goal of this research is to contribute to the advancement of personalized and targeted cancer therapy by developing innovative drug delivery systems that can improve treatment outcomes, reduce side effects, and enhance patient quality of life. The findings of this study have the potential to revolutionize the field of cancer treatment and pave the way for the development of more effective and patient-specific therapeutic strategies for combating cancer.