Thesis Abstract

Abstract
Cancer remains a major global health concern, with conventional treatment methods often associated with significant side effects and limited efficacy. The development of novel drug delivery systems for targeted cancer therapy has emerged as a promising approach to enhance the effectiveness of anticancer treatments while minimizing adverse effects on healthy tissues. This thesis focuses on the design, development, and evaluation of innovative drug delivery systems that can selectively target cancer cells, thereby improving treatment outcomes and patient quality of life. Chapter One provides an introduction to the research topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance of the study, structure of the thesis, and definition of key terms. The literature review in Chapter Two critically examines existing studies on drug delivery systems for cancer therapy, highlighting the advantages and limitations of various approaches, including nanoparticles, liposomes, micelles, and antibody-drug conjugates. Chapter Three outlines the research methodology employed in this study, including the selection of materials, formulation techniques, characterization methods, and in vitro/in vivo evaluation strategies. Key components of the methodology include the synthesis of novel drug carriers, encapsulation of anticancer agents, physicochemical characterization, cellular uptake studies, cytotoxicity assays, and animal model experiments. Chapter Four presents a detailed discussion of the findings obtained from the experimental work, focusing on the efficacy of the developed drug delivery systems in targeting cancer cells, enhancing drug delivery efficiency, and improving therapeutic outcomes. The results demonstrate the potential of the novel drug carriers to overcome biological barriers, increase drug accumulation in tumors, and induce selective cytotoxicity against cancer cells while sparing normal tissues. Finally, Chapter Five offers a comprehensive summary of the research findings, conclusions drawn from the study, implications for future research directions, and recommendations for the translation of the developed drug delivery systems into clinical practice. The thesis concludes with an emphasis on the importance of personalized and targeted approaches in cancer therapy and the crucial role of innovative drug delivery systems in advancing the field of oncology. In conclusion, the "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" thesis represents a significant contribution to the field of cancer research and drug delivery technology. The findings presented in this study hold great promise for improving the effectiveness and safety of cancer treatments, ultimately contributing to enhanced patient outcomes and quality of life in the fight against cancer.

Thesis Overview

The research project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the critical need for more effective and targeted treatment options for cancer patients. Cancer therapy, while advancing rapidly in recent years, still faces challenges such as systemic toxicity, drug resistance, and off-target effects. The development of novel drug delivery systems offers a promising approach to overcome these challenges and improve the efficacy and safety of cancer treatments. This research project will focus on designing and optimizing drug delivery systems that can specifically target cancer cells while sparing healthy tissues. The key objective is to enhance the therapeutic index of anticancer drugs by ensuring their precise delivery to the tumor site, thereby maximizing their efficacy and minimizing side effects. Various innovative strategies will be explored, including the use of nanoparticles, liposomes, micelles, and other nanoformulations to encapsulate and deliver anticancer agents. The research will involve a multidisciplinary approach, combining principles of chemistry, pharmacology, materials science, and nanotechnology. The project will include the synthesis and characterization of novel drug delivery systems, as well as in vitro and in vivo evaluations to assess their targeting efficiency, drug release kinetics, and therapeutic effects. Through a systematic and comprehensive investigation, the research aims to provide valuable insights into the design and optimization of drug delivery systems for targeted cancer therapy. Overall, this research project holds significant potential to advance the field of cancer treatment by developing innovative drug delivery systems that can revolutionize the way anticancer drugs are administered and improve patient outcomes. By enhancing the specificity and efficacy of cancer therapies while minimizing adverse effects, the development of novel drug delivery systems has the potential to make a substantial impact on the future of cancer treatment and patient care.