The effect of inhaled cannabis sativa and ascorbic acid (vitamin c) on the body weight, organ weight and sex hormone in male wistar rats
Table Of Contents
Title
Page – – – – – – – – – – i
Declaration – – – – – – – – – – ii
Certification – – – – – – – – – – iii
Dedication – – – – – – – – – – iv
Acknowledgements – – – – – – – – – v
Table
of contents – – – – – – – – – vi
Abstract – – – – – – – – – – xi
Chapter ONE
: INTRODUCTION
1.1
Background of Study – – – – – – – 1
1.2
Objective of Study- – – – – – – – – 4
1.3
Justification/Rationale for the Study- – – – – – 4
1.5 Significance
of the Study- – – – – – – 6
Chapter TWO
: LITERATURE
REVIEW
2.1
Cannabis Sativa Plant Description- – – – – – 6
2.1.1
Seedling:- – – – – – – – – – 7
2.1.2
Stem: – – – – – – – – – – 7
2.1.3
Leaves:- – – – – – – – – – 7
2.1.4
Buds or flowers on the cannabis plant:- – – – – 7
2.1.5
Smell of the cannabis plant, especially the leaves and flowers- – 8
2.1.6
Discovery and cultivation- – – – – – – 8
2.2 Scientific
Classification of Cannabis- – – – – – 9
2.2.1 Species of Marijuana– – – – – – – – 10
2.2.1.1
Cannabis sativa- – – – – – – – – 10
2.2.1.2 Cannabis
Indica- – – – – – – – 11
2.2.1.3 Cannabis
Ruderalis- – – – – – – – 12
2.3
Economic Importance of Marijuana- – – – – – 15
2.4
Constituents of Cannabis– – – – – – – – 17
2.4.1 Phytocannabinoids
— – – – – – – – 17
2.4.2 Classification- – – – – – – – – 18
2.4.3 Noncannabinoid-Type
Constituents- – – – – – 20
2.4.4 Hydrocarbons- – – – – – – – – 23
2.4.5 Nitrogen-Containing
Compounds – – – – 23
2.4.6 Carbohydrates- – – – – – – – – 24
2.4.7 Flavonoids- – – – – – – – – – 24
2.4.8 Fatty
Acids- – – – – – – – – – 25
2.4.9 Noncannabinoid
Phenols- – – – – – – 25
2.4.10 Other- – – – – – – – – – 26
2.4.11 Cannabinoid Receptor System- – – – – – 26
2.4.12 Cannabinoid 1 and 2 Receptors- – – – – – 27
2.5 Sex
Hormones and Its Synthesis- – – – – – 28
2.6 The
Protein Hormones- – – – – – – – 28
2.6.1 The
Gonadotropins- – – – – – – – 28
2.6.2 Luteinizing
Hormone (LH)- – – – – – – 29
2.6.3 Human
Chorionic Gonadotropin (hCG)- – – – – 30
2.6.4 Prolactin
(Prl)- – – – – – – – – 31
2.7 The
Steroid Hormones- – – – – – – – 32
2.7.1 Oestrogens- – – – – – – – – – 32
2.7.2 Oestradiol
(E2)- – – – – – – – – 32
2.7.3 Oestrone
(E1)- – – – – – – – – 33
2.7.4 Oestriol
(E3)- – – – – – – – – 33
2.7.5 Progesterone
(P4)- – – – – – – – – 34
2.7.6 Testosterone
(T)- – – – – – – – – 35
2.8 Cannabis
Effects- – – – – – – – – 35
2.8.1 Endocrine
effects – – – – – – – – 35
2.8.2 Hypothalamic Pituitary-Gonadal Axis – – – – – 35
2.9 Hpg Axis Effects In Males – – – – – – 37
2.9.1 Effects on Reproductive Hormones in Males – – – – 37
2.10 Effects on Prolactin – – – – – – – 39
2.10.1 Effects on other
Body Systems – – – – – 40
2.10.2 Vitamin C – – – – – – – – – 41
2.10.3 Biosynthesis and molecular structure of
vitamin C – – 43
2.10.4 Redox metabolism and antioxidant properties
of vitamin C- – 44
Thesis Abstract
Thesis Overview
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