Thesis Abstract

Abstract
The intricate regulation of skeletal muscle development and function is essential for maintaining overall health and proper physiological function. MicroRNAs (miRNAs) have emerged as key players in the post-transcriptional regulation of gene expression, influencing various biological processes, including muscle development and function. This thesis investigates the role of miRNAs in regulating skeletal muscle development and function, aiming to provide a comprehensive understanding of the molecular mechanisms involved. Chapter One provides an introduction to the topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance of the study, and the structure of the thesis. The chapter also includes definitions of key terms relevant to the research. Chapter Two comprises a detailed literature review that explores existing research on miRNAs and their involvement in skeletal muscle development and function. This chapter highlights ten key studies that have contributed significantly to the current understanding of miRNA-mediated regulation of skeletal muscle. Chapter Three outlines the research methodology employed in this study, covering aspects such as research design, participant selection, data collection methods, miRNA analysis techniques, and statistical analysis procedures. The chapter includes eight sub-sections detailing the specific methodologies used to investigate the role of miRNAs in skeletal muscle regulation. Chapter Four presents a thorough discussion of the findings obtained from the research. The chapter analyzes the impact of miRNAs on skeletal muscle development and function, discusses the mechanisms through which miRNAs exert their regulatory effects, and explores potential therapeutic implications of targeting miRNAs in muscle-related disorders. Chapter Five offers a comprehensive conclusion and summary of the thesis. The findings of the study are summarized, key insights are highlighted, and recommendations for future research directions are provided. The chapter underscores the significance of miRNAs in regulating skeletal muscle development and function and emphasizes the potential for further exploration in this field. In conclusion, this thesis delves into the intricate role of miRNAs in the regulation of skeletal muscle development and function, shedding light on the molecular mechanisms that underlie these processes. By elucidating the impact of miRNAs on skeletal muscle biology, this research contributes to advancing our understanding of muscle-related disorders and lays the groundwork for potential therapeutic interventions targeting miRNAs.

Thesis Overview

The project titled "The Role of MicroRNAs in Regulating Skeletal Muscle Development and Function" focuses on investigating the intricate relationship between microRNAs and the development and function of skeletal muscle. MicroRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression by targeting messenger RNA (mRNA) for degradation or translational inhibition. In recent years, research has revealed that microRNAs are involved in various physiological processes, including skeletal muscle development, regeneration, and function. This research aims to explore the specific microRNAs that are associated with skeletal muscle development and function, and how they influence key processes such as myogenesis, muscle hypertrophy, and muscle regeneration. By elucidating the regulatory mechanisms of these microRNAs, this study seeks to provide valuable insights into the molecular pathways involved in skeletal muscle development and function. The project will involve a comprehensive review of existing literature on microRNAs and skeletal muscle biology to establish a solid theoretical foundation. Subsequently, experimental approaches such as RNA sequencing, bioinformatics analysis, and molecular biology techniques will be employed to identify and characterize the microRNAs involved in skeletal muscle development and function. Through this research, we aim to contribute to the growing body of knowledge on the role of microRNAs in skeletal muscle biology and provide a better understanding of the molecular mechanisms underlying skeletal muscle development and function. The findings of this study may have implications for the development of novel therapeutic strategies for muscle-related disorders and conditions, ultimately contributing to advancements in the field of skeletal muscle research.