Project Abstract

The emergence and rapid spread of multidrug-resistant (MDR) bacterial pathogens pose a significant global health challenge, compromising the effectiveness of conventional antibiotics and threatening the treatment of infectious diseases. This project aims to investigate the antimicrobial potential of plant-derived compounds as an alternative and sustainable approach to combat these formidable bacterial threats. The ongoing crisis of antimicrobial resistance (AMR) has become a pressing concern, with the World Health Organization identifying it as one of the top 10 global public health threats facing humanity. MDR bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extensively drug-resistant (XDR) Pseudomonas aeruginosa, have developed resistance to multiple classes of antibiotics, rendering many treatment options ineffective. This alarming trend underscores the urgent need to explore new antimicrobial strategies, particularly those derived from natural sources, which may hold the key to overcoming the limitations of conventional antibiotics. In this project, we will focus on investigating the antimicrobial properties of a diverse array of plant-derived compounds, including essential oils, phytochemicals, and secondary metabolites. These natural compounds have long been recognized for their potential to exhibit potent antimicrobial activities, often displaying unique mechanisms of action that can circumvent the resistance mechanisms developed by bacterial pathogens. Through a systematic screening process, we will evaluate the efficacy of these plant-derived compounds against a panel of clinically relevant MDR bacterial strains, including those mentioned above. Advanced in vitro and in vivo testing will be conducted to assess the antimicrobial potency, mode of action, and potential synergistic effects when combined with conventional antibiotics. The project will also investigate the underlying molecular mechanisms by which these plant-derived compounds exert their antimicrobial effects, providing valuable insights into their potential as novel therapeutic agents. Furthermore, this project will explore the optimization and formulation of these plant-derived compounds to enhance their stability, bioavailability, and targeted delivery to the site of infection. By developing innovative delivery systems, we aim to improve the clinical applicability and therapeutic efficacy of these natural antimicrobials, ultimately providing new treatment options for patients suffering from infections caused by MDR bacterial pathogens. The successful completion of this project will contribute to the growing body of knowledge on the antimicrobial potential of plant-derived compounds and their role in addressing the global challenge of antimicrobial resistance. The findings may lead to the development of new antimicrobial agents, either as standalone treatments or as adjuvants to existing antibiotics, thereby expanding the therapeutic arsenal against these formidable bacterial threats. Additionally, the research outcomes may stimulate further exploration of natural sources as a sustainable and eco-friendly approach to combating infectious diseases in the face of the AMR crisis.

Project Overview