Project Abstract

Project Overview

<p> Title page – – – – – – – – – – – i<br>Approval Page- – – – – – – – – – – ii<br>Certification – – – – – – – – – – – iii<br>Dedication – – – – – – – – – – – iv<br>Acknowledgment – – – – – – – – – – v<br>Abstract – – – – – – – – – – – vi<br>Table of contents – – – – – – – – – -vii<br>List of Figures- – – – – – – – – – -viii<br>List of Abbreviations – – – – – – – – – – x<br>List of Tables – – – – – – – – – – -xi<br>CHAPTER ONE: INTRODUCTION<br>1.1 Background of study – – – – – – – – – 1<br>1.2 Statement of the Problem – – – – – – – – 4<br>1.3 Objectives of the Study – – – – – – – – 5<br>1.4 Justification of the Study – – – – – – – – 5<br>CHAPTER TWO: LITERATURE REVIEW<br>2.0 Linear Phenothiazine – – – – – – – – – 6<br>2.1 Synthesis of Triazaphenothiazine – – – – – – – 7<br>2.2 Synthesis of Tetraazaphenothiazine – – – – – – – 9<br>2.3 Angular Phenothiazine – – – – – – – -10<br>viii<br>2.4 Aza Analogue of Angular phenothiazine – – – – – -13<br>2.5 Linear Phenoxazine – – – – – – – – – 18<br>2.6 Angular Phenoxazine – – – – – – – – – 19<br>2.7 Aza- Analogue of Angular Phenoxazine – – – – – -23<br>2.8 Branched phenothiazine and Phenoxazine Compounds – – – – 27<br>CHAPTER THREE: EXPERIMENTAL<br>3.0 General Information – – – – – – – – – 35<br>3.1 6-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 35<br>3.2 14- Nitrobenzo[a][1,4]benzoxazino[3,2,-c]phenothiazine – – – -36<br>3.3 11-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – – 37<br>3.4 15-Amino-13-thiol-12,14-diazabenzo[a][1,4]benzoxazino[3,2- c]phenothiazine – 37<br>3.5 6,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 38<br>3.6 12-Chloro-9-methoxy-8-azabenzo[a][1,4]benzoxazino[3,2-c]phenothiazine – 38<br>3.7 Antimicrobial Activity – – – – – – – – 39<br>3.8 Sensitivity testing of compounds – – – – – – – 39<br>3.9 Minimum inhibitory concentration testing of compounds – – – – 40<br>CHAPTER FOUR: RESULTS AND DISCUSSION<br>4.1 6-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 41<br>4.2 11-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – -44<br>4.3 6,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 47<br>4.4 Result of Antimicrobial Sensitivity Test – – – – – – 50<br>ix<br>4.5 Minimum inhibitory Concentration Determination – – – – – 51<br>4.6 Result of Minimum Inhibitory Concentration – – – – – 52<br>CHAPTER FIVE<br>Conclusion – – – – – – – – – – – 53<br>References – – – – – – – – – – – 54 <br></p>