The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats..
Table Of Contents
Chapter ONE
1.1 Introduction1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms
Chapter TWO
2.1 Overview of Liver Functions2.2 Review of Previous Studies on Liver Health
2.3 Bioactive Compounds in Anchomanes difformis
2.4 Effects of Ethanolic Extracts on Liver Functions
2.5 Mechanisms of Liver Detoxification
2.6 Liver Diseases and Treatment
2.7 Impact of Herbal Extracts on Liver Health
2.8 Comparative Analysis of Herbal Extracts
2.9 Role of Antioxidants in Liver Protection
2.10 Conclusion of Literature Review
Chapter THREE
3.1 Research Design and Methodology3.2 Selection of Sample Population
3.3 Administration of Ethanolic Extract
3.4 Data Collection Methods
3.5 Statistical Analysis Techniques
3.6 Ethical Considerations
3.7 Research Limitations
3.8 Data Validity and Reliability
Chapter FOUR
4.1 Overview of Findings4.2 Effects of Anchomanes difformis Extract on Liver Enzymes
4.3 Histopathological Changes in Liver Tissues
4.4 Comparison with Control Groups
4.5 Impact on Liver Function Tests
4.6 Discussion of Results
4.7 Interpretation of Data
4.8 Implications for Liver Health
Chapter FIVE
5.1 Summary of Findings5.2 Conclusion
5.3 Recommendations for Future Research
5.4 Practical Applications of the Study
5.5 Contribution to Knowledge in Liver Health
Project Abstract
This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of Anchomanes difformis has a hepatotoxic effect. It showed that there was an insignificant increase (p>0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p>0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of Anchomanes difformis has a hepatotoxic effect in adult wistar rat.
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