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The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats

 

Table Of Contents


Chapter 1

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter 2

2.1 Overview of Liver Functions
2.2 Review of Liver Anatomy and Physiology
2.3 Previous Studies on Liver Function Tests
2.4 Effects of Herbal Extracts on Liver Functions
2.5 Role of Antioxidants in Liver Health
2.6 Liver Diseases and Their Impact
2.7 Pharmacological Properties of Anchomanes difformis
2.8 Studies on the Ethanol Extract of Anchomanes difformis
2.9 Mechanisms of Action of Ethanol Extract on Liver
2.10 Gaps in Current Literature

Chapter 3

3.1 Research Design and Methodology
3.2 Selection of Sample Population
3.3 Preparation of the Ethanol Extract
3.4 Animal Model and Experimental Setup
3.5 Administration of the Extract
3.6 Data Collection Methods
3.7 Variables and Parameters Measured
3.8 Statistical Analysis Techniques

Chapter 4

4.1 Overview of Research Findings
4.2 Effects of Anchomanes difformis Extract on Liver Enzymes
4.3 Impact on Liver Function Tests
4.4 Histological Changes in Liver Tissues
4.5 Comparison with Control Group
4.6 Correlation Analysis of Data
4.7 Discussion on Results
4.8 Implications for Liver Health

Chapter 5

5.1 Summary of Findings
5.2 Conclusion
5.3 Contributions to Existing Knowledge
5.4 Recommendations for Future Research
5.5 Practical Applications of the Study

Project Abstract

This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of Anchomanes difformis has a hepatotoxic effect. It showed that there was an insignificant increase (p>0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p>0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of Anchomanes difformis has a hepatotoxic effect in adult wistar rat.



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