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Estrogen receptor β and breast cancer

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Estrogen Receptor β and Breast Cancer
2.2 Historical Perspectives on Estrogen Receptor β Research
2.3 Molecular Mechanisms of Estrogen Receptor β in Breast Cancer
2.4 Role of Estrogen Receptor β in Breast Cancer Development
2.5 Clinical Implications of Estrogen Receptor β in Breast Cancer
2.6 Therapeutic Targeting of Estrogen Receptor β in Breast Cancer
2.7 Current Research Trends in Estrogen Receptor β and Breast Cancer
2.8 Knowledge Gaps and Future Directions in Estrogen Receptor β Research
2.9 Comparative Studies on Estrogen Receptor β and Other Biomarkers in Breast Cancer
2.10 Ethical Considerations in Estrogen Receptor β Research

Chapter THREE

3.1 Research Methodology Overview
3.2 Research Design and Approach
3.3 Data Collection Methods
3.4 Sampling Techniques
3.5 Data Analysis Procedures
3.6 Ethical Considerations in Research
3.7 Validity and Reliability Measures
3.8 Limitations of the Research Methodology

Chapter FOUR

4.1 Analysis of Research Findings
4.2 Estrogen Receptor β Expression Levels in Breast Cancer Samples
4.3 Correlation Between Estrogen Receptor β and Clinical Outcomes
4.4 Impact of Estrogen Receptor β Targeted Therapies
4.5 Comparison with Estrogen Receptor α in Breast Cancer
4.6 Molecular Signaling Pathways Involving Estrogen Receptor β
4.7 Evaluation of Treatment Response Based on Estrogen Receptor β Status
4.8 Discussion on Future Research Directions

Chapter FIVE

5.1 Conclusion and Summary
5.2 Recap of Key Findings
5.3 Implications for Clinical Practice
5.4 Contributions to the Field of Breast Cancer Research
5.5 Suggestions for Further Studies

Project Abstract

Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.

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