Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.
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The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Resistance" aims to investigate the intricate involvement of...
The project topic, "Exploring the Role of MicroRNAs in Cancer Development and Progression," focuses on investigating the intricate involvement of micr...
The project topic, "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Potential," delves into the intricate world of microRNAs and...
The project titled "Investigating the role of microRNAs in regulating gene expression in cancer cells" aims to delve into the intricate mechanisms by ...
The project titled "Exploring the Role of Epigenetics in Cancer Development and Therapeutic Approaches" aims to investigate the intricate relationship...
The project on "Identification and Characterization of Novel Enzymes Involved in Plant Secondary Metabolite Biosynthesis" aims to explore the intricat...
The project topic, "Exploring the Role of Gut Microbiota in Human Health and Disease," delves into the intricate relationship between gut microbiota a...
The project topic, "Investigating the Effects of Different pH Levels on Enzyme Activity in Biological Systems," focuses on exploring how varying pH le...
The project "Investigating the role of epigenetic modifications in cancer development and progression" aims to explore the intricate relationship betw...