Home / Biochemistry / Estrogen receptor β and breast cancer

Estrogen receptor β and breast cancer

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Estrogen Receptor β
2.2 Role of Estrogen Receptor β in Breast Cancer
2.3 Genetic Factors and Estrogen Receptor β Expression
2.4 Treatment Targeting Estrogen Receptor β
2.5 Clinical Studies on Estrogen Receptor β in Breast Cancer
2.6 Hormonal Regulation and Estrogen Receptor β
2.7 Estrogen Receptor β as a Prognostic Indicator
2.8 Estrogen Receptor β and Breast Cancer Recurrence
2.9 Estrogen Receptor β as a Therapeutic Target
2.10 Future Research Directions on Estrogen Receptor β

Chapter THREE

3.1 Research Methodology Overview
3.2 Research Design and Approach
3.3 Data Collection Methods
3.4 Sampling Techniques
3.5 Data Analysis Procedures
3.6 Ethical Considerations
3.7 Research Limitations
3.8 Validity and Reliability of Research

Chapter FOUR

4.1 Analysis of Research Findings
4.2 Estrogen Receptor β Expression Patterns
4.3 Impact of Estrogen Receptor β on Breast Cancer Progression
4.4 Comparison of ERβ Expression in Different Breast Cancer Subtypes
4.5 Therapeutic Implications of ERβ Targeting
4.6 Factors Influencing ERβ Expression Levels
4.7 Future Research Directions
4.8 Recommendations for Clinical Practice

Chapter FIVE

5.1 Summary of Research Findings
5.2 Conclusion
5.3 Implications of Research
5.4 Contributions to Knowledge
5.5 Recommendations for Future Research

Project Abstract

Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.

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