THE ANTI-INFLAMMATORY ACTIVITY OF Crateva adansonii DICHLOROMETHANE FRACTION
Table Of Contents
Chapter ONE
1.1 Introduction1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms
Chapter TWO
2.1 Overview of Inflammation2.2 Biological Basis of Inflammation
2.3 Anti-Inflammatory Agents
2.4 Phytochemicals with Anti-Inflammatory Activity
2.5 Previous Studies on Crateva adansonii
2.6 Pharmacological Properties of Crateva adansonii
2.7 Anti-Inflammatory Activity of Plant Extracts
2.8 Mechanisms of Action of Anti-Inflammatory Agents
2.9 Formulation of Plant Extracts
2.10 Bioavailability and Pharmacokinetics of Plant Compounds
Chapter THREE
3.1 Research Design and Methodology3.2 Selection of Research Materials
3.3 Extraction and Fractionation Techniques
3.4 In vitro Anti-Inflammatory Assays
3.5 In vivo Anti-Inflammatory Models
3.6 Data Collection Methods
3.7 Data Analysis Procedures
3.8 Ethical Considerations in Research
Chapter FOUR
4.1 Analysis of Extracted Compounds4.2 Evaluation of Anti-Inflammatory Activity
4.3 Comparison with Standard Drugs
4.4 Mechanistic Studies
4.5 Formulation Development
4.6 Pharmacokinetic Analysis
4.7 Safety and Toxicity Assessment
4.8 Interpretation of Results
Chapter FIVE
5.1 Summary of Findings5.2 Conclusion
5.3 Implications of the Study
5.4 Recommendations for Future Research
5.5 Contribution to the Field
Project Abstract
Crateva adansonii is a medicinal herb commonly used in parts of Africa because of the side effects of Non-Steroidal Anti-inflammatory Drugs (NSAID), like heart diseases and kidney failure. Inflammation is a major public heart issue in the world but treatment is becoming complex because of the side effects of anti-inflammatory pharmaceutical drugs. Hence the need for alternative drug is highly required. This research work investigated the anti-inflammatory activity of dichloromethane fraction of methanol extract of Crateva adansonii stem bark, using rodent model. Adult Swiss albino rats (110-200g) of either sex were randomlydivided into 5 groups of 4 animals each. Groups 2, 3, 4, and 5 received different doses of the extract (300mg, 500mg, 700mg, and 900mg) in 3% v/v tween 80 administered intraperitonally respectively. Control group-1 received volume of 3%v/v tween 80 and standards group received 100mg/kg Ibuprofen. One hour later acute inflammation was induced by injection of 0.1ml of undiluted egg albumin into the sub planter of the right hand paw of rats. The volume of the paw was measured by mercury displacement before and at 0.5, 1, 1.5, 2, 2.5 & 3 hours after egg albumin injection, while the standard was measured at internals of one hour, for up to 4 hours. Edema formation was assessed in terms of the difference in the zero time per volume of the injected pair and its volume at the different time after egg albumin injection. For each dose of extract, percentage inhibition of edema was calculated percentage inhibition. Result show that Crateva adansonii may have anti-inflammatory effects. This finding supports the use stem bark of Crateva adansonii in not only traditional medicine for the treatment of inflammation.
Project Overview
1.0 Introduction
Research on analgesic and anti-inflammatory drugs has gained great attention for the past ten years (Farouk et al., 2008). However, the number of new drugs remains low. Most analgesic and anti- inflammatory compounds available on market have adverse effects, including life-threatening, bleeding or perforation of gastro duodenal tract (Buttgereit et al., 2001). Consequently there results the need to search for more active compounds with less adverse effects.
Free radicals and reactive oxygen species are by products of numerous physiological and biochemical processes. Natural antioxidants and anti-inflammatoryeffects have been found in a number of food and agricultural products like seed, roots, stem bark. Besides the traditional resources used for antioxidants, many plant species have been investigated in the search for natural antioxidants and anti-inflammatory effect.
There is renewed and increased interest in plants as source of new pharmaceutical drugs. Crateva Adansonii commonly known as the garlic pear and temple plant and many other names in a variety of dialect has been viewed to have great anti inflammatory effect, thus studied here on.(Banias et al. 1992).
Anti-inflammation is therefore understood as a process in which the body responds to antigenic stimulus to injuries and infections in a coordinated manner in order to contain a site of change, localize the responds and restore tissue function .it involves the reaction of vascularized tissues to local injury and the local reaction and resulting morphological changes, the destruction or removal of infectious material etc. (Koch 1972).
Blazingprojects Mobile App
📚 Over 50,000 Project Materials
📱 100% Offline: No internet needed
📝 Over 98 Departments
🔍 Software coding and Machine construction
🎓 Postgraduate/Undergraduate Research works
📥 Instant Whatsapp/Email Delivery
Related Research
Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Resistance...
The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Resistance" aims to investigate the intricate involvement of...
Exploring the Role of MicroRNAs in Cancer Development and Progression...
The project topic, "Exploring the Role of MicroRNAs in Cancer Development and Progression," focuses on investigating the intricate involvement of micr...
Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Potential...
The project topic, "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Potential," delves into the intricate world of microRNAs and...
Investigating the role of microRNAs in regulating gene expression in cancer cells....
The project titled "Investigating the role of microRNAs in regulating gene expression in cancer cells" aims to delve into the intricate mechanisms by ...
Exploring the Role of Epigenetics in Cancer Development and Therapeutic Approaches...
The project titled "Exploring the Role of Epigenetics in Cancer Development and Therapeutic Approaches" aims to investigate the intricate relationship...
Identification and Characterization of Novel Enzymes Involved in Plant Secondary Met...
The project on "Identification and Characterization of Novel Enzymes Involved in Plant Secondary Metabolite Biosynthesis" aims to explore the intricat...
Exploring the Role of Gut Microbiota in Human Health and Disease...
The project topic, "Exploring the Role of Gut Microbiota in Human Health and Disease," delves into the intricate relationship between gut microbiota a...
Investigating the Effects of Different pH Levels on Enzyme Activity in Biological Sy...
The project topic, "Investigating the Effects of Different pH Levels on Enzyme Activity in Biological Systems," focuses on exploring how varying pH le...
Investigating the role of epigenetic modifications in cancer development and progres...
The project "Investigating the role of epigenetic modifications in cancer development and progression" aims to explore the intricate relationship betw...
