<p>1. Introduction<br> 1.1 Background and significance<br> 1.2 Objectives of the study<br>2. DNA structure and replication origins<br> 2.1 DNA double helix<br> 2.2 Replication origins and initiation<br>3. Enzymes and proteins involved in DNA replication<br> 3.1 DNA polymerases<br> 3.2 DNA helicases<br> 3.3 Single-stranded DNA-binding proteins<br> 3.4 Topoisomerases<br>4. DNA replication fork progression<br> 4.1 Leading and lagging strand synthesis<br> 4.2 Okazaki fragments<br> 4.3 DNA primase and RNA primers<br>5. DNA proofreading and error correction<br> 5.1 DNA exonucleases<br> 5.2 Mismatch repair mechanisms<br> 5.3 DNA damage tolerance pathways<br></p>
DNA replication is a fundamental process that ensures the faithful transmission of genetic information from one generation to the next. This project aims to study the mechanisms of DNA replication, focusing on the enzymes, proteins, and molecular events involved in DNA synthesis. By unraveling the intricacies of DNA replication, we can gain insights into genome stability, DNA repair mechanisms, and potential targets for anti-cancer therapies.
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