Project Abstract

Abstract
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. It plays a crucial role in regulating neuronal excitability and is involved in various physiological and pathological processes. GABA acts by binding to specific GABA receptors, which are classified into two main types GABA-A receptors and GABA-B receptors. These receptors are distributed throughout the brain and spinal cord, modulating the activity of neurons and influencing processes such as cognition, mood, and motor control. Research has shown that GABAergic dysfunction is implicated in a range of neurological and psychiatric disorders, including epilepsy, anxiety disorders, and depression. Understanding the role of GABA in these conditions has led to the development of pharmacological agents that target the GABA system. Drugs that enhance GABAergic activity, such as benzodiazepines and barbiturates, are commonly used to treat anxiety and sleep disorders. On the other hand, drugs that act as GABA receptor antagonists, like bicuculline, can induce seizures and are used in research to explore the mechanisms of epilepsy. In addition to its role as a neurotransmitter, GABA is also involved in non-synaptic signaling in the brain. GABA can be released from non-neuronal cells, such as astrocytes and microglia, and act on extrasynaptic GABA receptors to modulate neuronal activity. This extrasynaptic GABA signaling has been shown to play a role in neuroprotection, neurogenesis, and the regulation of synaptic plasticity. Furthermore, recent studies have highlighted the importance of the gut-brain axis in regulating GABAergic signaling. The gut microbiota can produce and release GABA, which can then act on GABA receptors in the enteric nervous system and signal to the central nervous system. This bidirectional communication between the gut and the brain has implications for various aspects of health, including stress responses, mood regulation, and metabolic functions. In conclusion, GABA is a multifaceted molecule with diverse functions in the nervous system. Its role as a neurotransmitter, neuromodulator, and signaling molecule highlights the complexity of GABAergic signaling and its involvement in both physiological processes and disease states. Further research into the mechanisms of GABAergic signaling may lead to the development of novel therapeutic strategies for neurological and psychiatric disorders.

Project Overview